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Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice
(Wiley, 2018-08)
The renin–angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effect, whereas the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against ...
Dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic chagas cardiomyopathy
(Karger, 2018-12)
Individuals who are infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and ...
Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity
(Elsevier Ireland, 2019-12)
The renin-angiotensin system modulates insulin action. Pharmacological stimulation of angiotensin type 2 receptor (AT2R) was shown to have beneficial metabolic effects in various animal models of insulin resistance and ...
Adiponectina: Una adipocitoquina con múltiples funciones protectorasAdiponectin: an adipocytokine with multiple protective functions
(Federación Bioquímica de la Provincia Buenos Aires, 2008-12)
Actualmente, se considera que el tejido adiposo es un órgano dinámico involucrado en muchos procesos fisiológicos y metabólicos. Expresa y secreta una gran variedad de péptidos activos conocidos como adipocitoquinas que ...
Ghrelin antagonist regulates metabolic hormone receptorsin the hypothalamus of ewes
(Elsevier, 2020-04)
This study evaluates the effects of ghrelin antagonist on mRNA abundance for metabolic hormone receptors in feed-restricted ewes. Ewes were randomly assigned to one of three treatments; Control (CO): feed above maintenance ...
Alterations in key metabolic sensors involved in bovine cystic ovarian disease
(Elsevier Science Inc, 2018-10)
High-producing dairy cows frequently suffer metabolic alterations that cause different diseases, which could decrease the reproductive efficiency of the herd. Among these reproductive disorders, cystic ovarian disease (COD) ...
Activation of angiotensin type 2 receptors prevents diabetic complications in female db/db mice by nitric oxide‐mediated mechanisms
(Wiley Blackwell Publishing, Inc, 2020-08)
Background and Purpose: The AT2 receptor plays a role in metabolism by opposing the actions triggered by the AT1 receptors. Activation of AT2 receptors has been shown to enhance insulin sensitivity in both normal and insulin ...
Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis
(Cambridge University Press, 2019-02)
Fetal programming by androgen excess is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). PCOS is more than a reproductive disorder, as women with PCOS also show ...
Natural products for the treatment of Type 2 Diabetes Mellitus
(Georg Thieme Verlag Kg, 2015-06)
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. ...