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FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...
Bradykinin mediates the association of collecting duct cells to form migratory colonies, through B2 receptor activation
(Wiley-liss, Div John Wiley & Sons Inc, 2018-08)
It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that ...
Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators
(American Chemical Society, 2021-08)
DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the sn-1 position, a common feature in this template, is relevant for C1 domain ...
New record of Phrikoceros inca (Polycladida, Cotylea) from the central coast of Peru, with a review of polyclads known from Peruvian waters
(Taylor & Francis Ltd, 2020-12-25)
Polyclads are marine free-living Platyhelminthes, generally disregarded in marine environmental assessments. Here, Phrikoceros inca (Cotylea, Pseudocerotidae), identified on the basis of external features such as its ...
Theoretical insight into the hydroxylamine oxidoreductase mechanism
(Elsevier Science Inc, 2008-07)
The multiheme enzyme hydroxylamine oxidoreductase from the autotrophic bacteria Nitrosomonas europaea catalyzes the conversion of hydroxylamine to nitrite, with a complicate arrangement of heme groups in three subunits. ...
Neotype Designation for the Marine Flatworm, Acanthozoon alderi (Polycladida: Cotylea: Pseudocerotidae), from India with Comments onthe Taxonomical Status of the Genus
(Academia Sinica, 2018-09-27)
Acanthozoon alderi is an ovoid, medium-sized pseudocerotid. Body margin ruffled; pseudotentacles black and pointed, with white tips. Dorsal surface covered with papillae, except for the cerebral region. Background colour ...
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
(Frontiers Media, 2020-04-15)
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking ...