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Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix
(Wiley-Blackwell, 1997-06-15)
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote ...
PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO SHARK CARTILAGE PROTEOGLYCAN
(Assoc Bras Divulg Cientifica, 1994-09-01)
1. Two proteoglycans, PG1 and PG2, have been isolated from shark cartilage. Both are highly polydisperse and large (molecular mass: 1-10 X 10(6) Daltons) and contain chondroitin sulfate and keratan sulfate side chains, but ...
Diabetes induces stromal remodelling and increase in chondroitin sulphate proteoglycans of the rat ventral prostate
(Wiley-Blackwell Publishing, Inc, 2009-08-01)
P>Extracellular matrix (ECM) remodelling is an important process involved in prostate cancer progression. Alterations in ECM caused by diabetes in different tissues such as kidney is well described; however, it is poorly ...
Proteoglycans and glycosaminoglycans synthesized in vitro by mesangial cells from normal and diabetic rats
(Elsevier B.V., 1996-05-21)
In the renal glomerulus, two extracellular matrices have been identified, the glomerular basement membrane and the mesangial matrix. Accumulation of glomerular extracellular matrix is a conspicuous feature of most forms ...
Effect of epithelial debridement on human cornea proteoglycans
(Associação Brasileira de Divulgação Científica, 2001-03-01)
Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained ...
Chondroitin sulfate proteoglycans are structural renewable constituents of the rabbit vitreous body
(Taylor & Francis Inc, 2005-05-01)
Purpose: To characterize the vitreous intrinsic proteoglycans, investigate their dynamics, and examine their role in the supramolecular organization of the vitreous. Methods: Vitreous from normal rabbits was collected and ...
Ultrastructural and immunohistochemical analysis of proteoglycans in mouse pubic symphysis
(Elsevier B.V., 2003-01-01)
Proteoglycans were accurately localized in mouse pubic symphyseal tissues using the cuprolinic blue method. Specific glycosaminoglycans degradative enzymes, together with chondroitin sulfate and decorin antibodies, allowed ...
GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN
(Atha Comunicacao & Editora, 2016)
Objective: To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods: This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with ...
Putative role of heparan sulfate proteoglycan expression and shedding on the proliferation and survival of cells after photodynamic therapy
(Elsevier B.V., 2007-01-01)
Introduction: Photodynamic therapy is based on the selective retention of a photosensitizer by highly proliferating cells and its activation with light at the appropriate wavelength. This combination generates reactive ...
Probing the interaction between heparan sulfate proteoglycan with biologically relevant molecules in mimetic models for cell membranes: A Langmuir film study
(Elsevier B.V., 2012-05-01)
Investigating the role of proteoglycans associated to cell membranes is fundamental to comprehend biochemical process that occurs at the level of membrane surfaces. in this paper, we exploit syndecan-4, a heparan sulfate ...