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Zinc fingers: DNA binding and protein-protein interactions
(Sociedad de Biología de Chile, 2000)
Aromatic clusters in protein-protein and protein-drug complexes
(BioMed Central, 2020-05)
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein-drug and protein-protein interactions. They are relevant for both protein stability and molecular recognition ...
Renaissance of Allostery to Disrupt Protein Kinase Interactions
(Elsevier Science London, 2019-11)
Protein–protein interactions often regulate the activity of protein kinases by allosterically modulating the conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ...
Protein-protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces
(John Wiley & Sons Inc, 2017-10)
Protein-protein interactions are essential to all aspects of life. Specific interactions result from evolutionary pressure at the interacting interfaces of partner proteins. However, evolutionary pressure is not homogeneous ...
Uncovering viral protein-protein interactions and their role in arenavirus life cycle
(MDPI, 2012-09)
The Arenaviridae family includes widely distributed pathogens that cause severe hemorrhagic fever in humans. Replication and packaging of their single-stranded RNA genome involve RNA recognition by viral proteins and a ...
An alternative easy method for antibody purification and analysis of protein-protein interaction-using GST fusion proteins immobilized onto glutathione-agarose
(Springer, 2014-01)
Immobilization of small proteins designed to perform protein-protein assays can be a difficult task. Often, the modification of reactive residues necessary for the interaction between the immobilized protein and the matrix ...
Intrinsic disorder associated with 14-3-3 proteins and their partners
(Elsevier, 2019-01)
Protein-protein interactions (PPIs) mediate a variety of cellular processes and form complex networks, where connectivity is achieved owing to the “hub” proteins whose interaction with multiple protein partners is facilitated ...
Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors
(Springer, 2018-05-01)
Chagas disease, a parasitic disease caused by Trypanosoma cruzi, is a major public health burden in poor rural populations of Central and South America and a serious emerging threat outside the endemic region, since the ...
Structural basis for the potent inhibition of the HIV integrase-LEDGF/p75 protein–protein interaction
(Elsevier Science Inc, 2017-08)
Integrase (IN) constitutes one of the key enzymes involved in the lifecycle of the Human Immunodeficiency Virus (HIV), the etiological agent of AIDS. The biological role of IN strongly depends on the recognition and binding ...