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Recognition-driven assembly of self-limiting supramolecular protein nanoparticles displaying enzymatic activity
(Royal Society of Chemistry, 2015-08-07)
We report the recognition-driven assembly of self-limiting protein nanoparticles displaying enzymatic activity. Solution self-assembly of concanavalin A lectin and glycoenzyme glucose oxidase leads to the spontaneous ...
Dynamically resolved self-assembly of S-layer proteins on solid surfaces
(Royal Society of Chemistry, 2018-08)
By using high-speed and high-resolution Atomic Force Microscopy (AFM), it was possible to resolve within a single experiment the kinetic pathway in S-layer self-assembly at the solid-liquid interface, obtaining a model ...
Self-Assembly Drugs: From Micelles to Nanomedicine
(Bentham Science Publishers, 2014)
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
Abstract: Engineering protein and peptide-based materials for drug delivery applications has
gained momentum due to their favorable biochemical and biophysical properties over synthetic
materials, including biocompatibility, ...
The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles
(Springer, 2022-06-17)
Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent cations. This fact allows the cost-effective, large-scale generation of microscopic ...
The role of flow in the self-assembly of dragline spider silk proteins
(Elsevier, 2023)
Hydrodynamic flow in the spider duct induces conformational changes in dragline spider silk proteins (spidroins) and drives their assembly, but the underlying physical mechanisms are still elusive. Here we address this ...
Engineering protein nanoparticles out from components of the human microbiome
(Wiley VCH Verlag, 2020-07-28)
Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective binding to specific cell surface receptors and penetration into ...
Low-fouling properties in serum of carboxylic-oligo(ethylene glycol)-based interfaces
(Elsevier B.V., 2021-06-05)
In the present work we evaluated the low-fouling feature of a carboxylic-oligo(ethylene glycol) self-assembled monolayer (carboxylic-OEG-SAM) interface using a quartz crystal microbalance with dissipation monitoring (QCM-D). ...