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RNA metabolism and ubiquitin/ubiquitin-like modifications collide
(Oxford University Press, 2012-11)
Alternative splicing and post-translational modifications are key events for the generation of proteome diversity in eukaryotes. The study of the molecular mechanisms governing these processes, and every other step of gene ...
Regulation of FKBP51 and FKBP52 functions by post-translational modifications
(Portland Press, 2019-10)
FKBP51 and FKBP52 are two iconic members of the family of peptidyl-prolyl-(cis/trans)-isomerases (EC: 5.2.1.8), which comprises proteins that catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds in unfolded ...
Ablation of arginyl-tRNA-protein transferase in oligodendrocytes impairs central nervous system myelination
(Wiley-liss, div John Wiley & Sons Inc., 2021-10)
Addition of arginine (Arg) from tRNA can cause major alterations of structure and function of protein substrates. This post-translational modification, termed protein arginylation, is mediated by the enzyme arginyl-tRNA-protein ...
Regulating the regulators: Serine/arginine-rich proteins under scrutiny
(John Wiley & Sons Inc, 2012-10)
Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeply studied role in splicing ...
Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi
(Public Library of Science, 2018-06)
Trypanosomes, protozoan parasites of medical importance, essentially rely on post-transcriptional mechanisms to regulate gene expression in insect vectors and vertebrate hosts. RNA binding proteins (RBPs) that associate ...
When SUMO met splicing
(Landes Bioscience, 2018-06)
Spliceosomal proteins have been revealed as SUMO conjugation targets. Moreover, we have reported that many of these are in a SUMO-conjugated form when bound to a pre-mRNA substrate during a splicing reaction. We demonstrated ...
Identification of new palmitoylated proteins in Toxoplasma gondii
(Elsevier Science, 2016-04)
Protein palmitoylation has been shown to be an important post-translational modification in eukaryotic cells. This modification alters the localization and/or the function of the targeted protein. In recent years, protein ...
Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
(Cambridge University Press, 2014-01)
Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated ...
Palmitoylation in apicomplexan parasites: from established regulatory roles to putative new functions
(Elsevier Science, 2019-06)
This minireview aims to provide a comprehensive synthesis on protein palmitoylation in apicomplexan parasites and higher eukaryotes where most of the data is available. Apicomplexan parasites encompass numerous obligate ...
New insights on enzyme stabilization for industrial biocatalysis
(American Chemical SocietyUnited States, 2022)