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Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
(International Research Journals Publishing House, 2011-09)
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems ...
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
(American Chemical Society, 2021-02)
Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach
(Springer Verlag Berlín, 2018-10)
Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the ...
Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies
(American Society of Tropical Medicine and Hygiene, 2016-08)
The aim of this study was to evaluate the effectiveness of benznidazole nanoparticles (BNZ-nps) on trypomastigote forms and on intracellular infection in mammalian cells and primary cardiac myocyte cells. Its effectiveness ...
The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components
(Springer, 2018-03-16)
Purpose: Solid dispersions (SDs) of a poorly water-soluble drug were prepared, and their physicochemical properties were compared to those of control physical mixtures (PMs). Among the multiple techniques used to characterize ...
Effect of α-tocopherol on the physicochemical, antioxidant and antibacterial properties of levofloxacin loaded hybrid lipid nanocarriers
(Royal Society of Chemistry, 2021-01)
In the global context of emerging pathogens associated with respiratory diseases, novel nanostructured lipid carriers (NLCs) having both antioxidant and antimicrobial properties produced by α-tocopherol (αT) and levofloxacin ...
Assessment of In vitro cytotoxicity of imidazole ionic liquids and inclusion in targeted drug carriers containing violacein
(Royal Society of Chemistry, 2020-08-10)
Violacein (Viol) is a pigment produced by several Gram-negative bacteria with many bioactivities, such as anticancer, virucide, and antiparasitic. However, violacein is insoluble under physiological conditions preventing ...
Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis
(Future Medicine, 2020-12)
Leishmaniasis is a neglected tropical disease and its cutaneous form manifests as ulcers or nodules, generally in exposed parts of the body. This work aimed to develop ivermectin (IVM) thermosensitive hydrogels as topical ...
Praziquantel systems with improved dissolution rate obtained by high pressure homogenization
(Elsevier Science, 2018-12-01)
Praziquantel (PZQ), an antihelmintic agent commonly administered to humans and cattle, has low aqueous solubility, which compromises its bioavailability and efficacy. The purpose of this study was to develop a new formulation, ...