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Photoreceptors in Chemotrophic Prokaryotes: The Case of Acinetobacter spp. Revisited
(Wiley Blackwell Publishing, Inc, 2015-09)
A comprehensive description of blue light using flavin (BLUF) photosensory proteins, including preferred domain architectures and the molecular mechanism of their light activation and signal generation, among chemotrophic ...
Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors
(Wiley Blackwell Publishing, Inc, 2009-09-10)
The insulin receptor (ir) and ir signaling proteins are widely distributed throughout the cns. ir signaling provides a trophic signal for transformed retinal neurons in culture and we recently reported that deletion of ir ...
Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors
(Association for Research in Vision and Ophthalmology, 2009-09)
PURPOSE. Identifying the cues required for survival and development of photoreceptors is essential for treating retina neurodegenerations. We previously established that glial derived neurotrophic factor (GDNF) stimulates ...
Ceramide Induces the Death of Retina Photoreceptors Through Activation of Parthanatos
(Springer, 2019-07)
Ceramide (Cer) has a key role inducing cell death and has been proposed as a messenger in photoreceptor cell death in the retina. Here, we explored the pathways induced by C2-acetylsphingosine (C2-Cer), a cell-permeable ...
Glucocorticoid and progesterone mechanisms in photoreceptor survival
(Academic Press Ltd - Elsevier Science Ltd, 2020-01)
Death of retinal photoreceptors is the basis of prevalent blinding diseases. Since steroids might have a therapeutic role in retinal degenerations, we compared the protective effects of dexamethasone and progesterone on ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Control of Plant Growth and Defense by Photoreceptors: From Mechanisms to Opportunities in Agriculture
(Oxford University Press, 2021-01)
Plants detect and respond to the proximity of competitors using light signals perceived by photoreceptor proteins. A low ratio of red to far-red radiation (R:FR ratio) is a key signal of competition that is sensed by the ...
Retinoid X Receptors Activation is Essential for Docosahexanoic Acid Protection of Retina Photoreceptors
(American Society For Biochemistry And Molecular Biology, 2013-05)
We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating ...
Non-linearities in the Rod and Cone Photoreceptor Inputs to the Afferent Pupil Light Response
(Frontiers Media SA, 2018-12)
Purpose: To assess the nature and extent of non-linear processes in pupil responses using rod- and cone-isolating visual beat stimuli. Methods: A four-primary photostimulating method based on the principle of silent ...
Light, lipids and photoreceptor survival: live or let die?
(Royal Society of Chemistry, 2015-09)
Due to its constant exposure to light and its high oxygen consumption the retina is highly sensitive to oxidative damage, which is a common factor in inducing the death of photoreceptors after light damage or in retina ...