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Effect of phenobarbital on inducing insecticide tolerance and esterase changes in Aedes aegypti (Diptera: Culicidae)
(Sociedade Brasileira de Genética, 2004-01-01)
The effect of phenobarbital (PB) on the induction of tolerance to the organophosphorous insecticide temephos (TE) was investigated in Aedes aegypti L4 larvae submitted to two different PB-treatments:(1) continuous treatment ...
Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver
(Pergamon-Elsevier B.V. Ltd, 2008-08-01)
Idiosyncratic hepatotoxicity is a well-known complication associated with aromatic antiepileptic drugs (AAED), and it has been suggested to occur due to the accumulation of toxic arene oxide metabolites. Although there is ...
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital
(Universidade de São Paulo (USP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), 1999-01-01)
O objetivo deste trabalho foi investigar os efeitos morfológicos do tratamento prolongado com fenobarbital, na consolidação de falha óssea diafisária, induzida no rádio esquerdo de rato. Ratos machos albinos da linhagem ...
Comparison of the effects of barbiturate, benzodiazepine and ketamine on visual evoked potentials in rabbits
(2005-07-01)
The aim of this study was to compare the effects of barbiturate, benzodiazepine and ketamine on flash-evoked potentials (F-VEP) in adult rabbits. A total of 36 animals were studied, 16 after pentobarbital endovenous (EV) ...
Cell-mediated and humoral immunity in West syndrome
(1981-01-01)
The immunological status of five children with West syndrome consequent to previous cerebral lesions was investigated. Three children had West syndrome and two were in transition from West to Lennox-Gastaut syndrome. All ...
ALTERED FOCI OF HEPATOCYTES IN RATS INITIATED WITH DIETHYLNITROSAMINE AFTER PROLONGED FASTING
(Elsevier B.V., 1993-09-01)
The influence of fasting on the potential of diethylnitrosamine (DEN) to initiate liver cucinogenesis was tested in a medium-term assay using the development of putative preneoplastic altered foci of hepatocytes (AFH) as ...
Effects of monocrotaline on energy metabolism in the rat liver
(Elsevier B.V., 2008-11-10)
Monocrotaline (MCT) is a pyrrolizidine alkaloid present in the plants of the Crotalaria species that causes cytotoxicity and genotoxicity in animals and humans, and it is hepatically metabolized to the alkylating agent ...
AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES
(Elsevier B.V., 1992-06-19)
Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. the lowest susceptibility ...
Infiltrating CD8(+) T lymphocytes, natural killer cells, and expression of IL-10 and TGF-beta 1 in chemically induced neoplasms in male Wistar rats
(Taylor & Francis Inc, 2004-09-01)
The present study aimed to estimate the number of CD8(+) T and natural killer (NK) infiltrating cells and the expression of interleukin-10 (IL-10) and transforming growth factor beta 1 (TGF-beta1) in chemically induced ...
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
(Elsevier Science Bv, 2016)
The efficiency of most of the new antiepileptic drugs (AEDs) on clinical trials still falls short the success reported in pre-clinical studies, possibly because the validity of the animal models is insufficient to fully ...