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Age-related changes in the response of intestinal cells to parathyroid hormone
(Elsevier Ireland, 2004-12)
The concept of the role(s) of parathyroid hormone (PTH), has expanded from that on acting on the classical target tissues, bone and kidney, to the intestine where its actions are of regulatory and developmental importance: ...
PTH stimulates PLCβ and PLCγ isoenzymes in rat enterocytes: influence of ageing
(Elsevier Science Inc, 2001-02)
We previously reported that in rat duodenal cells (enterocytes), parathyroid hormone (PTH [1–34]: PTH) stimulates the hydrolysis of polyphosphoinositides by phospholipase C (PLC), generating the second messengers inositol ...
The early phase of programmed cell death in Caco-2 intestinal cells exposed to PTH
(Wiley-liss, Div John Wiley & Sons Inc, 2008-01)
The regulation of apoptosis is critical for ensuring the homeostasis of an organism. As such, the cell has derived various mechanisms to precisely control the balance between survival and apoptotic signaling. Parathyroid ...
An altemative peptide sequencing procedure for low budget laboratories
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2011)
Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes
(Wiley-liss, Div John Wiley & Sons Inc, 2002-06)
Phosphoinositide-3-kinase (PI3K) is a lipid kinase, which phosphorylates the D3 position of phosphoinositides, and is known to be activated by a host of protein tyrosine kinases. PI3K plays an important role in mitogenesis ...
PTH and phospholipase A2 in the aging process of intestinal cells
(Wiley-liss, Div John Wiley & Sons Inc, 2004-12)
In this study we analyzed, for the first time, alterations in phospholipase A2(PLA2) activity and response to parathyroid hormone (PTH) in rat enterocytes with aging. We found that PTH, rapidly stimulate arachidonic acid ...
PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
(American Society for Bone and Mineral Research, 2011-05)
The periosteal and endocortical surfaces of cortical bone dictate the geometry and overall mechanical properties of bone. Yet the cellular and molecular mechanisms that regulate activity on these surfaces are far from being ...
Convergent signaling pathways regulate parathyroid hormone and fibroblast growth factor-23 action on NPT2A-mediated phosphate transport
(American Society for Biochemistry and Molecular Biology, 2016-09)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 ...
1α,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: Activation of cytosolic PLA2
(Pergamon-Elsevier Science Ltd, 2004-05)
In the current study, we have probed the role of cytosolic phospholipase A2 (cPLA2) activity in the cellular response to the calciotropic hormones, 1α,25,dihydroxy-vitamin D3 [1α,25(OH)2D 3] and PTH. Stimulation of rat ...
Tratamientos Anabólicos para Osteoporosis: Hormona Paratiroidea (Pth) Primera Parte
(Centro de Osteopatías Médicas, 2009-05)
El artículo revisa el uso de la hormona paratiroidea (PTH) en el tratamiento de la osteoporosis,cuyo efecto anabólico consiste en aumentar rápida y substancialmente la densidad mineral óseaprincipalmente a nivel de hueso ...