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Perforin and granzymes in neurological infections: From humans to cattle
(Elsevier, 2021-04)
Perforin and granzymes are essential components of the cytotoxic granules present in cytotoxic T lymphocytes and natural killer cells. These proteins play a crucial role in a variety of conditions, including viral infections, ...
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells
(The American Society of Gene & Cell Therapy, 2012-01)
The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death ...
The key to egress? Babesia bovis perforin-like protein 1 (PLP1) with hemolytic capacity is required for blood stage replication and is involved in the exit of the parasite from the host cell
(Elsevier, 2021-07)
Bovine babesiosis is a tick-borne disease caused by apicomplexan parasites of the Babesia genus that represents a major constraint to livestock production worldwide. Currently available vaccines are based on live parasites ...
Specific lytic activity against mycobacterial antigens is inversely correlated with the severity of tuberculosis
(Wiley Blackwell Publishing, Inc, 2003-06)
The ability of peripheral blood mononuclear cells (PBMC) from patients with active tuberculosis to display cytotoxic responses against autologous Mycobacterium tuberculosis (Mtb)-pulsed macrophages was evaluated. Non-MHC ...
Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum
(Elsevier, 2018)
Flavobacterium psychrophilum is the etiological agent of bacterial cold water disease (BCWD), also referred to as rainbow trout fry syndrome (RTFS), a disease with great economic impact in salmonid aquaculture. Despite ...
Novel role for animal innate immune molecules: Enterotoxic activity of a snail egg MACPF-Toxin
(Frontiers Media, 2020-03-13)
Gastropod Molluscs rely exclusively on the innate immune system to protect from pathogens, defending their embryos through maternally transferred effectors. In this regard, Pomacea snail eggs, in addition to immune defenses, ...
Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes
(Springer, 2021-06)
Purpose: γδ T lymphocytes are non-conventional T cells that participate in protective immunity and tumor surveillance. In healthy humans, the main subset of circulating γδ T cells express the TCRVγ9Vδ2. This subset responds ...
Regulatory functions of NK cells during infections and cancer
(Federation of American Societies for Experimental Biology, 2021-01)
After recognition, NK cells can kill susceptible target cells through perforin-dependent mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete cytokines that are pivotal for immunomodulation. ...
Macrophagic Activation Syndrome with Cytophagic Histiocytic Panniculitis in Pediatrics: Case ReportSíndrome de Activación Macrofágica con paniculitis histiocítica citofágica en pediatría: reporte de caso
(Intituto Tecnológico de Santo Domingo (INTEC), 2018)
Antigen-based nano-immunotherapy controls parasite persistence, inflammatory and oxidative stress, and cardiac fibrosis, the hallmarks of chronic chagas cardiomyopathy, in a mouse model of trypanosoma cruzi infection
(Multidisciplinary Digital Publishing Institute, 2020-02-21)
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 ...