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Plasmon-induced oxidative stress and macromolecular damage in pathogenic bacteria
(Royal Society of Chemistry, 2016-10)
The inactivation mechanism of bacterial growth by Photodynamic Antibacterial Chemotherapy (PACT) employing gold nanoparticles and gold core/silver shell aspartame stabilized bimetallic nanoparticles was studied. Reactive ...
Molecular pathways of nonalcoholic fatty liver disease development and progression
(Springer, 2019-01)
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic syndrome. It represents a wide spectrum of histopathological abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis ...
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy
(Academic Press Inc Elsevier Science, 2008-12)
Nitric oxide (NO) has emerged as an important endogenous inhibitor of apoptosis. In this study, we postulated that the mechanism of apoptosis inhibition by NO would include stimulation of heat shock protein 70 (Hsp70) ...
Climate change and the impact of greenhouse gasses: CO2 and NO, friends and foes of plant oxidative stress
(Frontiers Media S.A., 2018-03-01)
Here, we review information on how plants face redox imbalance caused by climate change, and focus on the role of nitric oxide (NO) in this response. Life on Earth is possible thanks to greenhouse effect. Without it, ...
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
(Pergamon-elsevier Science Ltd, 2012-10-17)
We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av ...
B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
(University of Science and Technology, 2015-03)
B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different ...
Oxidative stress generated by irradiation of a zinc(II) phthalocyanine induces a dual apoptotic and necrotic response in melanoma cells
(Springer, 2019-01)
Melanoma is an aggressive form of skin carcinoma, highly resistant to traditional therapies. Photodynamic therapy (PDT) is a non-invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant ...
Interferon-Β lipofection II: Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-Β gene transfer to human tumor cells
(Nature Publishing Group, 2012-06)
We evaluated the cytotoxic effects (apoptosis, necrosis and early senescence) of human interferon-B (hIFNB) gene lipofection. The cytotoxicity of hIFNB gene lipofection resulted equivalent to that of the corresponding ...
Differential effect of hyperglycaemia on the immune response in an experimental model of diabetes in BALB/cByJ and C57Bl/6J mice: participation of oxidative stress
(Wiley Blackwell Publishing, Inc, 2013-02-04)
Diabetes is associated with an increased risk of death from infectious disease. Hyperglycaemia has been identified as the main factor contributing to the development of diseases associated with diabetes mellitus. However, ...