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Probing conformational changes in orphan nuclear receptor: The NGFI-B intermediate is a partially unfolded dimer
(ELSEVIER SCIENCE BV, 2008)
Human nerve growth factor-induced B (NGFI-B) is a member of the NR4A subfamily of orphan nuclear receptors (NRs). Lacking identified ligands, orphan NRs show particular co-regulator proteins binding properties, different ...
Orphan nuclear receptor NGFI-B forms dimers with nonclassical interface
(2007-08-01)
The orphan receptor nerve growth factor-induced B (NGFI-B) is a member of the nuclear receptor's subfamily 4A (Nr4a). NGFI-B was shown to be capable of binding both as a monomer to an extended half-site containing a single ...
Orphan nuclear receptor NGFI-B forms dimers with nonclassical interface
(2007-08-01)
The orphan receptor nerve growth factor-induced B (NGFI-B) is a member of the nuclear receptor's subfamily 4A (Nr4a). NGFI-B was shown to be capable of binding both as a monomer to an extended half-site containing a single ...
Allosteric Pathways In The Ppar Gamma-rxr Alpha Nuclear Receptor Complex
(NATURE PUBLISHING GROUPLONDON, 2016)
Imunoexpressão da IL-17 e RORƴt em carcinomas de células escamosas de lábio e língua
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Patologia OralOdontologia, 2014-02-27)
Th17 cells have been strongly associated to the pathogenesis of inflammatory and autoimmune diseases, although their influence on the carcinogenesis is still little known, there are reports of anti-tumor and protumoral ...
Nuclear receptors: a historical perspective
(Springer Nature Group, 2019-05)
These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral ...