info:eu-repo/semantics/article
Nuclear receptors: a historical perspective
Fecha
2019-05Registro en:
Mazaira, Gisela Ileana; Zgajnar, Nadia Romina; Lotufo, Cecilia Maricel; Daneri Becerra, Cristina del Rosario; Sivils, Jeffrey C.; et al.; Nuclear receptors: a historical perspective; Springer Nature Group; Methods in Molecular Biology; 1966; 5-2019; 1-5
1064-3745
CONICET Digital
CONICET
Autor
Mazaira, Gisela Ileana
Zgajnar, Nadia Romina
Lotufo, Cecilia Maricel
Daneri Becerra, Cristina del Rosario
Sivils, Jeffrey C.
Soto, Olga B.
Cox, Marc B.
Galigniana, Mario Daniel
Resumen
These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral protein acquired various functions upon binding to preexisting small molecules, ligands. Currently, members of this receptor superfamily are categorized in six groups, including ?orphan receptors.? Research in the area has resulted in several clinically used drugs and continues to reveal further previously unknown roles for these receptors paving the road toward more valuable discoveries in the future.