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Microneedles rollers as a potential device to increase ALA diffusion and PpIX production: Evaluations by wide-field fluorescence imaging and fluorescence spectroscopy
(2014-01-01)
One of the limitations of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is the poor ability to penetrate biological barriers of skin and the recurrence rates in treatments. This study aimed to identify ...