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Regulatory roles of microtubule-associated proteins in neuronal morphogenesis. Involvement of the extracellular matrix
(Associacao Brasileira de Divulgacao Cientifica, 1999)
As a result of recent investigations, the cytoskeleton can be viewed as a cytoplasmic system of interconnected filaments with three major integrative levels: self-assembling macromolecules, filamentous polymers, e.g., ...
Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system
(Academic Press Inc., 2010)
The molecules and networks involved in the process of acquisition and maintenance of the form of a mature neuron are not completely known. Using a misexpression screen we identified the gene hindsight as a gene involved ...
RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons
(2012)
The formation of the nervous systems requires processes that coordinate proliferation, differentiation and migration of neuronal cells, which extend axons, generate dendritic branching and establish synaptic connections ...
Heparin activates Wnt signaling for neuronal morphogenesis
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-09)
Writ factors are secreted ligands that affect different aspects of the nervous system behavior like neurodevelopment, synaptogenesis and neurodegeneration. In different model systems, Wnt signaling has been demonstrated ...
WNT signaling in neuronal maturation and synaptogenesis
(Frontiers, 2013-07)
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key ...
Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth
(The Company of Biologists, 2013)
Although progress has been made in resolving the genetic pathways that specify neuronal asymmetries in the brain, little is known
about genes that mediate the development of structural asymmetries between neurons on left ...
Regulation of spine density and morphology by IQGAP1 protein domains
(Public Library Science, 2013-02)
IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin ...
Pea3 transcription factors, Etv4 and Etv5, are required for proper hippocampal dendrite development and plasticity
(Oxford University Press, 2016-11)
The proper formation and morphogenesis of dendrites is essential to the establishment of neuronal connectivity. We report that 2 members of the Pea3 family of transcription factors, Etv4 and Etv5, are expressed in hippocampal ...