Buscar
Mostrando ítems 1-6 de 6
An alternative synthetic route to the neuroleptic compound Pipothiazine
(Arkat USA, 2009-05)
A simple and efficient synthesis of the neuroleptic compound Pipothiazine 1 is described, involving the reductive cyclation of (2-nitrophenyl)(phenyl)sulfanes 3 for the formation of the phenothiazine ring.
Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
(Springer, 2005-10)
Rationale: The rewarding effects of lateral hypothalamic brain stimulation, various natural rewards, and several drugs of abuse are attenuated by D1 or D2 dopamine receptor (D1R or D2R) antagonists. Much of the evidence ...
Dopaminergic drugs in type 2 diabetes and glucose homeostasis
(Elsevier, 2016-07)
The importance of dopamine in central nervous system function is well known, but its effects on glucose homeostasis and pancreatic β cell function are beginning to be unraveled. Mutant mice lacking dopamine type 2 receptors ...
An astroglia-linked dopamine D2-receptor action in prefrontal cortex
(National Academy of Sciences, 2001-02)
Typical neuroleptic drugs elicit their antipsychotic effects mainly by acting as antagonists at dopamine D2 receptors. Much of this activity is thought to occur in the cerebral cortex, where D2 receptors are found largely ...
A Review of Clinical and Economic Evaluations Applied to Psychotropic Therapies Used in the Treatment of Schizophrenia in Argentina
(Springer International Publishing, 2017-10)
Schizophrenia is considered a serious mental disorder that affects over 21 million people worldwide, and is associated with disability that frequently affects the patient's educational and working performance. In Argentina, ...
Expanding the phenotype of phosphomannomutase-2 gene congenital disorder of glycosylation: Cervical dystonia
(Elsevier Science, 2017-07)
Dear EditorPhosphomannomutase-2 deficiency-congenital disorder of glycosylation (PMM2-CDG), congenital disorder of glycosylation type-Ia or Jaeken syndrome (MIM #601785) is an autosomal recessive inherited condition of ...