Buscar
Mostrando ítems 1-10 de 56
Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation
(Frontiers Media, 2015)
Multiple sclerosis (MS) is the principal cause of autoimmune neuroinflammation in humans, and its animal model, experimental autoimmune encephalomyelitis (EAE), is widely used to gain insight about their immunopathological ...
Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches
(Frontiers Research Foundation, 2014)
Alzheimer disease (AD) is the most common cause of dementia in people over 60 years
old. The molecular and cellular alterations that trigger this disease are still diffuse, one
of the reasons for the delay in finding an ...
The Unfolded protein response in immune cells as an emerging regulator of neuroinflammation
(Frontiers Media, 2021)
Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent ...
Oxidative stress and neuroinflammation as a pivot in drug abuse. A focus on the therapeutic potential of antioxidant and anti-inflammatory agents and biomolecules
(MDPI, 2020)
Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...
Tau oligomers and fibrils induce activation of microglial cells
(IOS Press, 2013)
Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures
(Elsevier, 2018-05)
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, ...
Psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk
(Acta Dermato-Venereologica, 2020)
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired ...
Pathway to Tau Modifications and the Origins of Alzheimer's Disease
(Elsevier Inc., 2018)