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Neurogenetics in Peru: clinical, scientific and ethical perspectives
(Springer, 2015)
Neurogenetics, the science that studies the genetic basis of the development and function of the nervous system, is a discipline of recent development in Peru, an emerging Latin American country. Herein, we review the ...
Whole exome sequencing in neurogenetic odysseys: An effective, cost- and time-saving diagnostic approach
(Public Library of Science, 2018-02)
Background Diagnostic trajectories for neurogenetic disorders frequently require the use of considerable time and resources, exposing patients and families to so-called “diagnostic odysseys”. Previous studies have provided ...
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
(Elsevier, 2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches ...
The odyssey of complex neurogenetic disorders: From undetermined to positive
(Wiley-liss, div John Wiley & Sons Inc., 2020-12)
The genetic and phenotypic heterogeneity of neurogenetic diseases forces patients and their families into a ?diagnostic odyssey.? An increase in the variability of genetic disorders and the corresponding gene-disease ...
The Biology of Paternal Care in Human and Nonhuman Primates
(Annual Reviews, 2009-10)
Among primates, intense paternal care is manifested in only a few distantly related species, including humans. Thus, neither purely phylogenetic nor socioecological hypotheses can explain its presence or the variability ...
Genetics of hereditary motor and sensory neuropathy and the Costa Rican contribution
(Universidad de Costa Rica, 2004)
AVPR1A Sequence Variation in Monogamous Owl Monkeys (Aotus azarai) and Its Implications for the Evolution of Platyrrhine Social Behavior
(Springer, 2010-09)
The arginine vasopressin V1a receptor gene (AVPR1A) has been implicated in increased partner preference and pair bonding behavior in mammalian lineages. This observation is of considerable importance for studies of social ...
Progress in progestin-based therapies for neurological disorders
(Pergamon-Elsevier Science Ltd, 2021-03)
Hormone therapy, primarily progesterone and progestins, for central nervous system (CNS) disorders represents an emerging field of regenerative medicine. Following a failed clinical trial of progesterone for traumatic brain ...
A journey to ‘tame a small metazoan organism’, ‡ seen through the artistic eyes of C. elegans researchers
(Taylor & Francis Ltd, 2020-12-08)
In the following pages, we share a collection of photos, drawings, and mixed-media creations, most of them especially made for this JoN issue, manifesting C. elegans researchers’ affection for their model organism and the ...