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Effect of nωnla, an inhibitor of No-synthase, on the release of tissue-plasminogem activator from rat aorta
(2003-12-01)
Alterations in the synthesis or enhanced inactivation of nitric oxide (NO) and increase in fibrin deposition in the vascular bed lead to an imbalance that can induced intravascular coagulation. NO is produced through ...
Inducible nitric oxide synthase polymorphisms and nitric oxide levels in individuals with chronic periodontitis
(2017-06-15)
This study aimed to investigate whether the –1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2–) and/or ...
Myenteric denervation in gastric carcinogenesis: Differential modulation of nitric oxide and annexin-A1
(2013-01-01)
This study evaluated the properties of endogenous nitric oxide synthases (NOS) and annexin-A1 (ANXA1) and determined how they can be exploited in the N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis ...
A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway
(ELSEVIER SCIENCE BV, 2008)
There is evidence that nitric oxide plays a role in the neurotransmitter balance within the basal ganglia and in the pathology of Parkinson`s disease. In the present work we investigated in striatal 6-hydroxydopamine ...
Expression of inducible nitric oxide synthase is increased in acute myeloid leukaemia
(KargerBaselSuíça, 2001)
Effect of NωNLA or dexamethasone on vascular hyporeactivity induced by E. coli endotoxin in sham and adrenalectomized rats
(2000-12-01)
Induction of iNOS by bacterial products is considered to be part of the defense mechanism against infection. However, it has been suggested that the bacterial-induced NO-overproduction may be involved in the vascular ...
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
(2013-01-01)
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes ...