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Tinnitus: Network path physiology-network pharmacology
(Frontiers, 2012-01)
Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant ...
Therapeutic approaches to the treatment of tinnitus
(Annual Reviews, 2019-01)
Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In the absence of external stimuli, phantom perceptions of sounds emerge from alterations in neuronal activity within central ...
Efficacy of pharmacological therapies for the prevention of fractures in postmenopausal women: A network meta-analysis
(Oxford University Press, 2019)
Background: Osteoporosis and osteopenia are associated with increased fracture incidence in postmenopausal women. We aimed to determine the comparative effectiveness of various available pharmacological therapies. Methods: ...
Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine
(Elsevier, 2021)
Ethnopharmacological relevance: Fungal and bacterial infections remain a major problem worldwide, requiring the development of effective therapeutic strategies. Solanum mammosum L. (Solanaceae) (“teta de vaca”) is used in ...
Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility
(Endocrine Society, 2012-12)
Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. ...
Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis
(Oxford University Press, 2018)
Background: Several pharmacologic treatments for hirsutism are used in practice; however, their relative efficacy is unclear. Methods: We searched MEDLINE, EMBASE, and CENTRAL through January 2017 for randomized controlled ...
Repurposing drugs to target nonalcoholic steatohepatitis
(W J G Press, 2019-04-21)
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of ...
Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine
(El SevierReino Unido, 2021-07-31)
Ethnopharmacological relevance: Fungal and bacterial infections remain a major problem worldwide, requiring the development of effective therapeutic strategies. Solanum mammosum L. (Solanaceae) (“teta de vaca”) is used in ...
Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
(MDPI, 2020-05)
Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the ...