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How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
(Smart Science & Technology, 2014-02)
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ...
Anxiety and depression symptoms disrupt resting state connectivity in patients with genetic generalized epilepsies
(Wiley-Blackwell, 2019-04-01)
Objective To analyze the lifetime trajectories in genetic generalized epilepsies (GGEs) and investigate the impact of symptoms of anxiety and depression on resting state functional connectivity (FC). Methods Seventy-four ...
Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
(Wiley, 2014-01)
Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for ...
Computational approaches for innovative antiepileptic drug discovery
(Taylor & Francis, 2016-10)
Introduction: Despite the approval of a large number of antiepileptic agents over the past 25 years, there has been no significant improvement in efficacy of treatments, with one third of patients suffering from intractable ...
Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Effectiveness of non-pharmacological strategies in the management of type 2 diabetes in primary care: A protocol for a systematic review and network meta-analysis
(2020-01-12)
Introduction Despite the increasing number of drugs and various guidelines on the management of type 2 diabetes mellitus (T2DM), several patients continue with the disease uncontrolled. There are several non-pharmacological ...
Pharmacological characterization of cnidarian extracts from the Caribbean Sea: Evaluation of anti-snake venom and antitumor properties
(2018-08-28)
Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study ...
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention
(John Wiley & Sons Inc, 2017-04-13)
We read with great interest the article of Ajmera et al. (1) reporting on the relationship between bio- markers and the histological disease spectrum of nonal- coholic fatty liver disease (NAFLD) in a large population ...
Functional organization of tau proteins during neuronal differentiation and development.
(1995)
Tau proteins play major regulatory roles in the organization and integrity of the cytoskeletal network. In neurons, a specific axonal compartmentalization of tau has been shown. However, recent studies demonstrate that tau ...
Corticofugal modulation of peripheral auditory responses
(Frontiers Research Foundation, 2015)
© 2015 Terreros and Delano.The auditory efferent system originates in the auditory cortex and projects to the medial geniculate body (MGB), inferior colliculus (IC), cochlear nucleus (CN) and superior olivary complex (SOC) ...