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1α,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation
(Company of Biologists Ltd, 2018-05-14)
We have previously shown that Solanum glaucophyllum leaf extract (SGE) increases VDR protein levels and promotes myoblast differentiation. Here, we investigated whether p38 MAPK and AKT are involved in SGE actions. Cell-cycle ...
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness
(Wiley, 2014-07)
Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen ...
The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability
(Wiley Blackwell Publishing, Inc, 2019-03)
Aim: Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction ...
The dietary lipid content affects the tissue gene expression of muscle growth biomarkers and the GH/IGF System of pejerrey (Odontesthes bonariensis) juveniles
(MDPI, 2019-06)
Gene expression of growth hormone receptors (GHRs), insulin-like growth factors (IGFs), myostatin (MSTN) and myogenin (MyoG) was analyzed in juveniles pejerrey fed with graded levels of lipids (L): 6% (L6), 10% (L10), 25% ...
1α,25(OH)2D3-dependent modulation of Akt in proliferating and differentiating C2C12 skeletal muscle cells
(Wiley-liss, Div John Wiley & Sons Inc, 2012-08)
We previously reported that 1α,25‐dihydroxy‐vitamin D3 [1α,25(OH)2D3] induces non‐transcriptional rapid responses through activation of Src and MAPKs in the skeletal muscle cell line C2C12. In the present study we investigated ...