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Effects of monocrotaline on energy metabolism in the rat liver
(Elsevier B.V., 2008-11-10)
Monocrotaline (MCT) is a pyrrolizidine alkaloid present in the plants of the Crotalaria species that causes cytotoxicity and genotoxicity in animals and humans, and it is hepatically metabolized to the alkylating agent ...
Dehydromonocrotaline inhibits mitochondrial complex 1. A potential mechanism accounting for hepatotoxicity of monocrotaline
(Elsevier B.V., 2007-10-01)
Monocrotaline is a pyrrolizidine alkaloid present in plants of the Crotalaria species, which causes cytotoxicity and genotoxicity, including hepatotoxicity in animals and humans. It is metabolized by cytochrome P-450 in ...
Cytotoxicity of monocrotaline in isolated rat hepatocytes: Effects of dithiothreitol and fructose
(Pergamon-Elsevier B.V. Ltd, 2011-06-01)
Monocrotaline (MCT) is a pyrrolizidine alkaloid present in plants of the Crotalaria species that causes cytotoxicity and genotoxicity, including hepatotoxicity in animals and humans. It is metabolized by cytochrome P-450 ...
Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure
(Springer, 2011-06-01)
Heart failure (HF) is characterized by limited exercise tolerance, skeletal muscle atrophy, a shift toward fast muscle fiber, and myogenic regulatory factor (MRF) changes. Reactive oxygen species (ROS) also contribute to ...
Experimental and theoretical studies on the characterization of monocrotaline by infrared and Raman spectroscopies
(Journal of Molecular Structure, 2018)
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
(American Journal of Physiology-Heart and Circulatory Physiology, 2018)
Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys
(2013-09-01)
The effects and susceptibility of donkeys to Crotalaria juncea and Crotalaria retusa poisoning were determined at high and low doses. Seeds of C. juncea containing 0.074% of dehydropyrrolizidine alkaloids (DHPAs) ...
Dehydromonocrotaline induces cyclosporine A-insensitive mitochondrial permeability transition/cytochrome c release
(Pergamon-Elsevier B.V. Ltd, 2009-07-01)
Monocrotaline (MCT) is a pyrrolizidine alkaloid present in plants of the genus Crotalaria that causes cytotoxicity and genotoxicity in animals and humans. It is well established that the toxicity of MCT results from its ...
Morphological aspects of neuromuscular junctions and gene expression of nicotinic acetylcholine receptors (nAChRs) in skeletal muscle of rats with heart failure
(Springer, 2011-12-01)
HF is syndrome initiated by a reduction in cardiac function and it is characterized by the activation of compensatory mechanisms. Muscular fatigue and dyspnoea are the more common symptoms in HF; these may be due in part ...
Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy
(Springer, 2010-02-01)
Heart failure (HF) is characterized by a reduced tolerance to exercise due to early fatigue and dyspnea; this may be due in part to skeletal muscle myopathy with a shift from slow to fast fibers and loss of muscle mass. ...