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Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening
(American Physiological Society, 2011-04)
Inhibition of Na +/H + exchanger 1 (NHE1) reduces cardiac ischemia-reperfusion (I/R) injury and also cardiac hypertrophy and failure. Although the mechanisms underlying these NHE1-mediated effects suggest delay of mitochondrial ...
A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response
(Springer Nature, 2017-02)
Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, ...
Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation
(Elsevier Science Inc, 2017-01)
Cyclophilin D (CyPD), a mitochondrial matrix protein, has been widely studied for its role in mitochondrial-mediated cell death. Unexpectedly, we previously discovered that overexpression of CyPD in a stable cell line, ...
Rosuvastatin protects isolated hearts against ischemia-reperfusion injury: role of Akt-GSK-3β, metabolic environment, and mitochondrial permeability transition pore
(Servicio Publicaciones Universidad Navarra, 2020-01)
The cardioprotective activity of rosuvastatin (R) is yet to be known. The objective of this study was to research whether R perfusion before global ischemia can mitigate myocardial ischemia-reperfusion damage, considering ...
The effect of nitric oxide on mitochondrial respiration
(Academic Press Inc Elsevier Science, 2019-07)
This article reviews the interactions between nitric oxide (NO)and mitochondrial respiration. Mitochondrial ATP synthesis is responsible for virtually all energy production in mammals, and every other process in living ...
Nitrosative stress in human spermatozoa causes cell death characterized by induction of mitochondrial permeability transition-driven necrosis
(Asian Society of Andrology, 2018-11)
Peroxynitrite is a highly reactive nitrogen species and a potent inducer of apoptosis and necrosis in somatic cells. Peroxynitrite-induced nitrosative stress has emerged as a major cause of impaired sperm function; however, ...
Mitochondrial function and nitric oxide production in hippocampus and cerebral cortex of rats exposed to enriched environment
(Elsevier Science, 2010-03)
Male rats (21 days) were assigned to enriched environment (EE) or to standard environment (SE) for 1 year. Oxygen consumption and the sensitivity to calcium induced mitochondrial permeability transition (MPT), through ...
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide
(Springer, 2011-05)
The objective of this study is to assess the participation of mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels in the cardioprotective effects of the Na(+)/H(+) exchanger (NHE-1) blocker cariporide in ...
Ketamine treatment affects hippocampal but not cortical mitochondrial function in prepubertal rats
(Pergamon-Elsevier Science Ltd, 2020-02)
Previous reports have shown that ketamine triggered apoptosis in immature developing brain involving mitochondrial-mediated pathways. However, no data for ketamine effects on hippocampal and cortical mitochondrial function ...