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Alterations in Nitric Oxide Synthase Activity and Expression in Submandibular Glands of NOD Mice
(Academic Press Inc Elsevier Science, 2001-10)
Abstract The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated ...
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
(Cell Press, 2017-02)
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling ...
Sex-dependent effects of a yoghurt enriched with proteins in a mouse model of diet-induced obesity
(Elsevier, 2021-03)
Using a mouse model of diet-induced obesity in males and females C57BL/6 mice, effects of a yoghurt enriched with proteins on pro-inflammatory cytokine and lipid profiles were assessed. A clear sex-dependent behaviour of ...
Evaluation of immune response, microbiota, and blood markers after probiotic bacteria administration in obese mice induced by a high-fat diet
(Elsevier Science Inc, 2014-11)
Objective: Obesity is associated with alterations in intestinal microbiota and immunity. The aim of this study was to determine the effect of probiotic Lactobacillus casei CRL 431 administration on intestinal and humoral ...
Effects of bile acid sequestration on hepatic steatosis in obese mice
(Mexican Association of Hepatology, 2014-01)
Background: Bile acid sequestration (BAS) with resins has shown antidiabetic effects in both humans and animals. Since hepatic steatosis is commonly associated to type 2 diabetes mellitus and the effects of BAS on steatosis ...
Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
(Nature Publishing Group, 2021-12)
This study investigated the immune mechanisms whereby administration of Bacteroides uniformis CECT 7771 reduces metabolic dysfunction in obesity. C57BL/6 adult male mice were fed a standard diet or a Western diet high in ...
“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”
(Elsevier Science, 2020-07)
Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal movements, insulinand glucose homeostasis, lipid metabolism and energy balance. This study evaluates the role of SPX in theimprovement ...
A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
(Elsevier, 2018-09)
This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced ...
Increased astrocyte reactivity in the hippocampus of murine models of type I diabetes: the non-obese diabetic (NOD) and the streptozotocin-treated mice
(Elsevier Science, 2002-11)
Diabetes can be associated with cerebral dysfunction in humans and animal models of the disease. Moreover, brain anomalies and alterations of the neuroendocrine system are present in type 1 diabetes (T1D) animals, such as ...
Inflammatory pathways regulated by tumor necrosis receptor-associated factor 1 protect from metabolic consequences in diet-induced obesity
(Lippincott Williams, 2018-03)
Rationale: The coincidence of inflammation and metabolic derangements in obese adipose tissue has sparked the concept of met-inflammation. Previous observations, however, suggest that inflammatory pathways may not ultimately ...