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Arctic char ( Salvelinus alpinus ) metallothionein: cDNA sequence, expression, and tissue-specific inhibition of cadmium-mediated metallothionein induction by 17β-estradiol, 4-OH-PCB 30, and PCB 104
(Society of Environmental Toxicology and Chemistry, 2000-03)
In this study, we haveexamined the basallevel expression and tissue‐specificexpressionpatternsof metallothionein (MT) in Arctic char following metal and E2 (17β‐estradiol) treatment. To study the gene regulation in Arctic ...
Metallothionein expression in colorectal cancer: Relevance of different isoforms for tumor progression and patient survival
(W B Saunders Co-Elsevier Inc, 2012-02)
Metallothioneins are a family of small, cysteine-rich proteins with many functions. Immunohistochemical evaluation of all metallothionein 1 + 2 isoforms in colorectal tumors has demonstrated an important down-regulation ...
The role of metallothioneins, selenium and transfer to offspring in mercury detoxification in Franciscana dolphins (Pontoporia blainvillei)
(Pergamon-Elsevier Science Ltd, 2016-08-19)
The concentrations of mercury (Hg), selenium (Se) and metallothioneins (MT) were evaluated in fetuses, calves, juveniles and adults of the endangered coastal Franciscana dolphin (Pontoporia blainvillei) from Argentina. ...
Blood cadmium and metallothionein concentrations in females of two sympatric pinnipeds species
(Pergamon-Elsevier Science Ltd, 2017-05-30)
Otaria flavescens (SASL) and Arctocephalus australis (SAFS) are endemic of South America. The aims were to assess Cd concentrations in red blood cells (RBC) and plasma from free living females of both species; and to ...
Uptake and detoxification of trace metals in estuarine crabs: insights into the role of metallothioneins
(Springer Heidelberg, 2020-06-06)
The detoxification process of trace metals in the estuarine burrowing crab Neohelice granulata, after previously being exposed to anthropogenic pressures in the field, is described for the first time. The objectives of ...
A TEM-traceable physiologically functional gold nanoprobe that permeates non-endocytic cells
(Dove Press, 2018-11)
Background: Nanoparticles’ intracellular fate requires proper internalization. Most cells make use of a battery of internalization pathways, but some are practically sealed, as they lack the biochemical machinery for ...
Toxicological responses of Laeonereis acuta (Polychaeta, Nereididae) after acute, subchronic and chronic exposure to cadmium
(Academic Press Inc Elsevier Science, 2018-03)
The objective of this study was to analyze the toxicological responses of the estuarine polychaete Laeonereis acuta after acute (96 h), subchronic (7 days) and chronic (14 days) exposure to cadmium (Cd). Concentrations of ...
Strategies for cadmium detoxification in the white shrimp Palaemon argentinus from clean and polluted field locations
(Pergamon-Elsevier Science Ltd, 2019-06)
In this study, we investigated the metal handling capacity of non-tolerant and tolerant populations of Palaemon argentinus to cadmium (Cd), through evaluating of the main mechanisms of metal detoxification, metallothioneins ...
Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy
(American Association for Cancer Research, 2014-03)
Metallothioneins (MT) are a family of low molecular weight proteins that are silenced during colorectal cancer progression, mainly through epigenetic mechanisms, and this loss is associated with poor survival. In this ...
Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect
(Frontiers Media, 2021-07)
Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico ...