Now showing items 1-10 of 46
Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Hybrid compounds as anti-infective agents
(Bentham Science Publishers, 2017-04)
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Computational approaches for innovative antiepileptic drug discovery
(Taylor & Francis, 2016-10)
Introduction: Despite the approval of a large number of antiepileptic agents over the past 25 years, there has been no significant improvement in efficacy of treatments, with one third of patients suffering from intractable ...
Migration transparency in agent systems
(Ieice-inst Electronics Information Communications EngTokyoJapão, 2000)
Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: Purification and characterization
(Elsevier B.V., 2006-04-01)
Tuberculosis (TB) poses a major worldwide public health problem. The increasing prevalence of TB, the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, the causative agent of TB, and the devastating ...
Antimicrobial susceptibility in Chile 2012 Susceptibilidad antimicrobiana en Chile 2012
(Sociedad Chilena de Infectologia, 2014)
Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 ...
Non-Target Effects of Dalaca pallens Blanchard Control Examined Through Principal Response Curves: A Guild Approach in Southern Chile
(Instituto de Investigaciones Agropecuarias, INIA, 2008)
While we wait for a vaccine against SARS-CoV-2, why not think about available drugs?
(Frontiers Media, 2020)
Abstract: At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, ...
Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis
Systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and ...