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MAGE-C1/CT7 and MAGE-C2/CT10 are frequently expressed in multiple myeloma and can be explored in combined immunotherapy for this malignancy
(Springer, 2013-01-01)
The exact function of MAGE-C1/CT7 and MAGE-C2/CT10 is not yet understood in multiple myeloma (MM). However, the homologs MAGE-C1/CT7 and MAGE-C2/CT10 genes encode highly immunogeneic cancer/testis antigens (CTAs) and can ...
Functional interaction between co-expressed MAGE-A proteins
(Public Library of Science, 2017-05)
MAGE-A (Melanoma Antigen Genes-A) are tumor-associated proteins with expression in a broad spectrum of human tumors and normal germ cells. MAGE-A gene expression and function are being increasingly investigated to better ...
MAGE Proteins and the Regulation of E2F Pathway
(SciMed Central, 2017-04)
Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors ...
Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma
(WILEY-BLACKWELLHOBOKEN, 2013-08-02)
Background Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer-testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety ...
Tumor-specific MAGE proteins as regulators of p53 function
(Elsevier Ireland, 2012-12)
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. ...
Descubrimiento de las propiedades oncogénicas de los antígenos MAGEDiscovering the oncogenic properties of MAGE antigens
(Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica, 2017-12)
Desde su descubrimiento como antígenos en células de melanoma humano, la interpretaciónde las proteínas MAGE (Melanoma Antigen GEnes) ha variado mucho. Se ha pasado de verlascomo moléculas promisorias para desarrollar ...
Estudio sobre funciones específicas de proteínas MAGE-I y su relevancia en oncologíaStudy on specific functions of MAGE-I proteins and its relevance in oncology
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2015)
Human MageB2 protein expression enhances E2F transcriptional activity, cell proliferation, and resistance to ribotoxic stress
(American Society for Biochemistry and Molecular Biology, 2015-12)
MageB2 belongs to the melanoma antigen gene (MAGE-I) family of tumor-specific antigens. Expression of this gene has been detected in human tumors of different origins. However, little is known about the protein function ...
Carta de padrões de relevo: município de Magé, RJ
(CPRM, 2018)