Artículos de revistas
Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma
Fecha
2013-08-02Registro en:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, HOBOKEN, v. 34, n. 8, supl. 1, Part 4, pp. 1123-1128, AUG, 2012
1043-3074
10.1002/hed.21880
Autor
de Moura Campos Montoro, Jose Raphael
Martins Mamede, Rui Celso
Serafini, Luciano Neder
Saggioro, Fabiano Pinto
Alves Figueiredo, David Livingstone
da Silva, Wilson Araujo, Jr.
Jungbluth, Achim A.
Spagnoli, Giulio Cesare
Zago, Marco Antonio
Institución
Resumen
Background Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer-testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs are considered potential targets for cancer vaccines. It is possible that the CTA MAGE-A4 (melanoma antigen) and MAGE-C1 are expressed in carcinoma of the oral cavity and are related with survival. Methods This study involved immunohistochemical analysis of 23 patients with oral squamous cell carcinoma (SCC) and was carried out using antibodies for MAGE-A4 and MAGE-C1. Fisher's exact test and log-rank test were used to evaluate the results. Results The expression of the MAGE-A4 and MAGE-C1 were 56.5% and 47.8% without statistical difference in studied variables and survival. Conclusion The expression of at least 1 CTA was present in 78.3% of the patients, however, without correlation with clinicopathologic variables and survival. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012