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Role of non-statin lipid-lowering therapy in coronary atherosclerosis regression: A meta-analysis and meta-regression
(BioMed Central, 2020-05)
Background: Several studies have investigated the association between non-statin lipid-lowering therapy and regression of atherosclerosis. However, these studies were mostly small and their results were not always robust. ...
Impact of Lipid-Lowering Therapy on Mortality According to the Baseline Non-HDL Cholesterol Level: A Meta-Analysis
(Springer, 2019-08)
Introduction: Previous report showed that more intensive lipid-lowering therapy was associated with less mortality when baseline LDL-C levels were > 100 mg/dL. Non-HDL-C is a better predictor of cardiovascular risk than ...
Human α-galactosidase a mutants: Priceless tools to develop novel therapies for fabry disease
(MDPI AG, 2021-06)
Fabry disease (FD) is a lysosomal storage disease caused by mutations in the gene for the α-galactosidase A (GLA) enzyme. The absence of the enzyme or its activity results in the accumulation of glycosphingolipids, mainly ...
Why Is Less Cationic Lipid Required To Prepare Lipoplexes from Plasmid DNA than Linear DNA in Gene Therapy?
(American Chemical Society, 2011-11)
The most important objective of the present study was to explain why cationic lipid (CL)-mediated delivery of plasmid DNA (pDNA) is better than that of linear DNA in gene therapy, a question that, until now, has remained ...
Pectin-Coated Plasmonic Nanoparticles for Photodynamic Therapy: Inspecting the Role of Serum Proteins
(American Chemical Society, 2021-05)
Plasmonic metal nanoparticles (NPs) can be used as enhancers of the efficiency of standard photosensitizers (PSs) in photodynamic therapy (PDT). Protein corona, the adsorption layer that forms spontaneously around NPs once ...
Helicobacter pylori eradication therapy in an area of southeastern Brazil: a cohort study
(Universidade Federal de Santa Maria, 2022)
Statin use in patients with elevated serum hepatic transaminases at baseline: A meta-analysis
(Elsevier, 2021-05)
Aims: Clinical trials showed that statin therapy decreased cardiovascular events without significantly raising the level of transaminases. However, the information in subjects with altered liver test at baseline is more ...
Treatment Strategies for Early-Stage Chronic Lymphocytic Leukemia: Can Interferon-Inducible MxA Protein and Tumor Necrosis Factor Play a Role as Predictive Markers for Response to Interferon Therapy?
(Mary Ann Liebert, 1996-07)
The potential benefit of interferon (IFN)-α therapy in early-stage B cell chronic lymphocytic leukemia (BCLL) patients is still under discussion, and no assays are available to distinguish potential responders from ...
Electrical stimulation of the lower esophageal sphincter to address gastroesophageal reflux disease after sleeve gastrectomy
(Elsevier Science Inc, 2019-05)
Background: Laparoscopic sleeve gastrectomy (LSG) can result in de novo and worsen preexisting gastroesophageal reflux disease (GERD). Post-LSG patients with GERD refractory to proton pump inhibitors (PPI) usually undergo ...