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Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease
(Lippincott Williams, 2020-04-04)
OBJECTIVE:Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works ...
The lipidome in nonalcoholic fatty liver disease: Actionable targets
(American Society for Biochemistry and Molecular Biology, 2021-05)
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. Recent technological advances, combined with OMICs experiments and explorations involving different biological samples, have ...
A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A2 on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A2α
(Molecular Diversity Preservation International, 2020-06)
Phospholipase A2s constitute a wide group of lipid‐modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry‐based lipidomic approaches to investigate ...
Evaluation of pro-inflammatory events induced by Bothrops alternatus snake venom
(Elsevier Ireland, 2018-02)
Inflammation is a major local feature of envenomation by bothropic snakes being characterized by a prominent local edema, pain, and extensive swelling. There are reports demonstrating that whole Bothrops snake venoms and ...
Alteration of sphingolipids in biofluids: Implications for neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute, 2019-07-21)
Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), ...
Coupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma
(American Chemical Society, 2020-11)
A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell renal cell carcinoma (ccRCC) stages I, II, III, and IV (n = 112) and controls (n = 52) was performed using ...
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy
(American Chemical Society, 2019-02)
Technological advances in mass spectrometry 14 (MS), liquid chromatography (LC) separations, nuclear 15 magnetic resonance (NMR) spectroscopy, and big data 16 analytics have made possible studying metabolism at an 17 “omics” ...
Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process
(Academic Press Inc Elsevier Science, 2019-08-27)
This study shows the effects of tamoxifen, a known estrogen receptor antagonist used in the treatment of breast cancer, on the sphingolipid pathway of Trypanosoma cruzi, searching for potential chemotherapeutic targets. A ...
Interaction of N -acetylcysteine with DPPC liposomes at different pH: a physicochemical study
(Royal Society of Chemistry, 2020-08)
The N-acetylcysteine (NAC) is a commonly used mucolytic and antioxidant agent. The knowledgeof interactions of the NAC with cell membranes is important to understand its mechanism ofpharmacological action at the molecular ...
The hypoxic microenvironment induces stearoyl-coa desaturase-1 overexpression and lipidomic profile changes in clear cell renal cell carcinoma
(MDPI, 2021-06)
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cell carcinoma (RCC). It is characterized by a high cell proliferation and the ability to store lipids. Previous studies have ...