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Triolein reduces MMP-1 upregulation in dermal fibroblasts generated by ROS production in UVB-irradiated keratinocytes
(Elsevier Ireland, 2017-02)
Background: Cytokine production and oxidative stress generated by ultraviolet radiation B (UVB) skin exposure are main factors of skin photoaging. Interleukin-6 (IL-6) produced by irradiated keratinocytes is proposed to ...
Dopamine agonists upregulate IL-6 and IL-8 production in human keratinocytes
(Karger, 2012-10)
Aim: Catecholamines regulate functions of the nervous, neuroendocrine and immune systems. Dopamine may modulate the activity of keratinocytes, which play a role in secreting cytokines and chemokines. The aim of this study ...
Differential Response of Dopamine Mediated by β-Adrenergic Receptors in Human Keratinocytes and Macrophages: Potential Implication in Wound Healing
(Karger, 2018-03)
Objective: Dopamine is an immunomodulatory neurotransmitter. In the skin, keratinocytes and macrophages produce proinflammatory cytokines and metalloproteinases (MMPs) which participate in wound healing. These cells have ...
Drug vulnerabilities and disease prognosis linked to the stem cell-like gene expression program triggered by the RHO GTPase activator VAV2 in hyperplastic keratinocytes and head and neck cancer
(Molecular Diversity Preservation International, 2020-09)
We have recently shown that VAV2, a guanosine nucleotide exchange factor that catalyzes the stimulation step of RHO GTPases, is involved in a stem cell-like (SCL) regenerative proliferation program that is important for ...
Lipoteichoic acid challenge induces higher inflammatory responses than lipopolysaccharide in UV irradiated keratinocytes
(Wiley Blackwell Publishing, Inc, 2015-03)
In the present work, we aimed to evaluate how UVR exposure could affect keratinocytes antimicrobial inflammatory response to gram-positive and gramnegative bacteria components, such as LTA and LPS. We observed that UVR ...
Cultivos de queratinocitos derivados de piel humana modificados genéticamente
(Universidad de Antioquia, Facultad de MedicinaGrupo de Inmunología Celular e InmunogenéticaMedellín, Colombia, 2022)