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Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels
(Society for Neuroscience, 2014-12-03)
Neurons use glucose to fuel glycolysis and provide substrates for mitochondrial respiration, but neurons can also use alternative fuels that bypass glycolysis and feed directly into mitochondria. To determine whether ...
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide
(Springer, 2011-05)
The objective of this study is to assess the participation of mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels in the cardioprotective effects of the Na(+)/H(+) exchanger (NHE-1) blocker cariporide in ...
Reperfusion arrhythmias increase after superior cervical ganglionectomy due to conduction disorders and changes in repolarization
(Molecular Diversity Preservation International, 2020-03)
Pharmacological concentrations of melatonin reduce reperfusion arrhythmias, but less is known about the antiarrhythmic protection of the physiological circadian rhythm of melatonin. Bilateral surgical removal of the superior ...
The mKATP Channels and protein-kinase C Are Involved in the Cardioprotective Effects of Genistein on Estrogen-Deficient Rat Hearts Exposed to Ischemia/Reperfusion
(Lippincott Williams, 2020-05)
Estrogenic deficiency is considered a risk of coronary disease in women. The phytoestrogen genistein could be a safe preventive strategy. The first aim of this work was to validate a model of cardiac stunning in which ...
Ischemic Postconditioning Reduces Reperfusion arrhythmias by Adenosine Receptors and Protein Kinase C Activation but Is Independent of KATP Channels or Connexin 43
(Molecular Diversity Preservation International, 2019-11)
Ischemic postconditioning (IPoC) reduces reperfusion arrhythmias but the antiarrhythmic mechanisms remain unknown. The aim of this study was to analyze IPoC electrophysiological effects and the role played by adenosine A1, ...
Lepidium meyenii (maca) and soy isoflavones reduce cardiac stunning of ischemia-reperfusion in rats by mitochondrial mechanisms
(Elsevier, 2021-11)
Background and aim: Phytoestrogens are traditionally used for cardiovascular risks but direct effects on the ischemic heart remain unclear. Plants with phytoestrogens are used for reducing menopausic symptoms and they could ...
Low-flow ischaemia and reperfusion in rat hearts: energetic of stunning and cardioprotection of genistein
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2018-09)
Objectives: Low-flow ischemia (LFI) is consequent to coronary disease and produces cardiac stunning during reperfusion (R). Energetic performance and mechanisms of Ca2+ handling during LFI/R are not known. Moreover, ...
Endothelium-dependent desensitization to angiotensin II in rabbit aorta: the mechanisms involved
(Canadian Science Publishing, 2001-12)
The aim of this study was to characterize the role of the endothelium in angiotensin II-desensitization and its mechanisms of action. Rabbit aortic rings were exposed to increasing doses of angiotensin II (Ang II, 10–9 to ...
Bacterial lipopolysaccharide protects the retina from light-induced damage
(Wiley, 2012-07)
Light-induced damage is a widely used model to study retinal degeneration. We examined whether bacterial lipopolysaccharide (LPS) protects the retina against light-induced injury. One day before intense light exposure for ...
The Anrep effect requires transactivation of the epidermal growth factor receptor
(Wiley Blackwell Publishing, Inc, 2010-05)
Myocardial stretch elicits a biphasic contractile response: the Frank-Starling mechanism followed by the slow force response (SFR) or Anrep effect. In this study we hypothesized that the SFR depends on epidermal growth ...