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Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
(1998-10-01)
Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients
(Associação Brasileira de Divulgação Científica (ABRADIC), 2003-03-01)
To identify early metabolic abnormalities in type 2 diabetes mellitus, we measured insulin secretion, sensitivity to insulin, and hepatic insulin extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree ...
Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
(1997-03-01)
Malnutrition is related to diabetes in tropical countries. In experimental animals, protein deficiency may affect insulin secretion. However, the effect of malnutrition on insulin receptor phosphorylation and further ...
Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models
(Springer, 2011-04-01)
Protein restriction at early stages of life reduces beta-cell volume, number of insulin-containing granules, insulin content and release by pancreatic islets in response to glucose and other secretagogues, abnormalities ...
Lack of insulin inhibition on insulin secretion in non-diabetic morbidly obese patients
(Nature Publishing GroupBasingstokeInglaterra, 2001)
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
(Amer Inst NutritionBethesdaEUA, 1998)
Subclinical abnormalities of glucose metabolism in Brazilian women with a history of gestational diabetes mellitus
(Blackwell Munksgaard, 2004-12-01)
Background. To evaluate insulin release and insulin sensitivity in women with prior gestational diabetes mellitus (GDM) to gain a better understanding of type 2 diabetes pathogenesis.Methods. GDM women were individually ...
Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations
(ELSEVIER SCI LTDOXFORD, 2012)
Background and aims: Although studies have shown association of birth weight (BW) and adult body mass index (BMI) with insulin sensitivity in adults, there is limited evidence that BW is associated with insulin secretion. ...
Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion
(Lippincott Williams, 2015-08)
Objective: To demonstrate the role of islet glucokinase, glucose metabolism, and intracellular insulin mediators in the enhancing effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) on glucoseinduced ...
Normal insulin sensitivity in lean offspring of obese parents
(North Amer Assoc Study ObesitySilver SpringEUA, 2004)