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Mensageiros secundários relacionados à ação dos hormônios vegetais
(2011)
The current knowledge about the mechanisms of action of plant hormones is still fragmented and incomplete. However, it’s known that the regulatory action and that the potential of signal amplification of these molecules ...
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
(BioMed Central Ltd., 2014)
© 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
Endoplasmic reticulum mitochondria calcium communication and the regulation of mitochondrial metabolism in cancer: a novel potential target
(Frontiers media SA, 2017)
Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to ...
Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity
(NATURE PUBLISHING GROUP, 2008)
Background and purpose: Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology. We have carried out morphological, biochemical and functional assays to investigate the ...
Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
(Public Library of Science, 2015-01)
The functional properties of inositol(1,4,5)-triphosphate (IP3) receptors allow a variety of intracellular Ca2+ phenomena. In this way, global phenomena, such as propagating and abortive Ca2+ waves, as well as local events ...
Regulation of Multidrug Resistance-Associated Protein 2 by Calcium Signaling in Mouse Liver
(JOHN WILEY & SONS INC, 2010)
Mu hiding resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by insertion into the plasma membrane; however, the factors that ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015)
Abstract: The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs ...
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism
(BioScientifica Ltd., 2014)
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor ...
Lithium decreases the effects of neuronal calcium sensor protein 1 on pedunculopontine neurons
(Physiological Society, 2016-03)
Human postmortem studies reported increased expression of neuronal calcium sensor protein 1 (NCS-1) in the brains of some bipolar disorder patients, and reduced or aberrant gamma band activity is present in the same disorder. ...
Identification of phospholipase activity in Rhinella arenarum sperm extract capable of inducing oocyte activation
(Cambridge University Press, 2013-09)
Egg activation, which includes cortical granule exocytosis, resumption and completion of meiosis and pronuclear formation culminates in the first mitotic cleavage. However, the mechanism through which the fertilizing sperm ...