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The performance of a migrating corrosion inhibitor suitable for reinforced concrete
(Springer, 2003-12)
The protection provided by a migrating corrosion inhibitor (MCI) based on an alkylaminoalcohol was tested on concrete specimens containing reinforcing steel bar (rebar) segments. Two inhibitor dosages were investigated, ...
Purification and characterization of a novel trypsin inhibitor from Solanum tuberosum subsp. andigenum var. overa: Study of the expression levels and preliminary evaluation of its antimicrobial activity
(Elsevier Science, 2020-09-01)
Protease inhibitors (PIs) have been traditionally recognized by their potential biomedical application in events with exacerbation of endogenous proteases activity. Plant PIs have gained interest as naturally occurring ...
Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII: The out of the active site pocket for the design of selective inhibitors?
(Taylor & Francis Ltd, 2021-10-04)
New C-glycosides and a,b-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of ...
Purification and characterization of a novel thermostable papain inhibitor from Moringa oleifera with antimicrobial and anticoagulant properties
(Multidisciplinary Digital Publishing Institute, 2021-04)
Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification ...
Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors
(Academic Press Inc Elsevier Science, 2020-01)
Sphingosine-1-phosphate is now emerging as an important player in cancer, inflammation, autoimmune, neurological and cardiovascular disorders. Abundance evidence in animal and humans cancer models has shown that SphK1 is ...
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
(Arkat USA, 2011-02)
A series of 4-[(triazolyl)methoxy]phenyl analogs of the phenoxyphenyl-substituted thiirane SB-3CT 1 was evaluated for its ability to inhibit gelatinases, members of the matrix metalloproteinase family of enzymes. The ...
Design, synthesis and evaluation of cholinesterase hybrid inhibitors using a natural steroidal alkaloid as precursor
(Academic Press Inc Elsevier Science, 2021-06-11)
To date, Alzheimers disease is the most alarming neurodegenerative disorder worldwide. This illness is multifactorialin nature and cholinesterase inhibitors have been the ones used in clinical treatments. In this context,many ...
Factor VIII genotype characterization of haemophilia A affected patients with transient and permanent inhibitors: A comprehensive Argentine study of inhibitor risks
(Wiley Blackwell Publishing, Inc, 2013-07)
Inhibitor development against exogenous factor VIII is a severe impairment of replacement therapy affecting 18% of Argentine patients with severe haemophilia A (HA). To study the molecular predisposition for inhibitor ...
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy
(Bentham Science Publishers, 2013-04)
As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds ...
Enantioselective synthesis of new oxazolidinylthiazolidines as enzyme inhibitors
(Pergamon-Elsevier Science Ltd, 2017-01)
The synthesis of new oxazolidinylthiazolidines bicycles, oxygen analogues of bisthiazolidines, also known as metallo-β-lactamase inhibitors is described. The reaction of β-aminoalcohols and 2,5-dihydroxy-1,4-dithiane led ...