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Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies
(2018-04-01)
We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI). A total of 10 BALB/C mice were used. Animals in group 1 received ...
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
(Macmillan Publisher Limited, 2009-05)
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding ...
Mucosal immune tolerance at the ocular surface in health and disease
(Wiley Blackwell Publishing, Inc, 2017-04)
The ocular surface is constantly exposed to environmental irritants, allergens and pathogens, against which it can mount a prompt immune response to preserve its integrity. But to avoid unnecessary inflammation, the ocular ...
Immune cells and oxidative stress in the endotoxin tolerance mouse model
(Associação Brasileira de Divulgação Científica, 2010)
Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses ...
A sweet path toward tolerance in the gut
(Nature Publishing Group, 2010-10)
Uncovering how the immune system of the mucosa surmounts allergic reactions may open new avenues to treat inflammatory conditions in the gut. New findings in mice now show that a C-type lectin receptor in dendritic cells ...
Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED
(SPRINGER/PLENUM PUBLISHERS, 2008)
Background Several primary immune deficiency disorders are associated with autoimmunity and malignancy, suggesting a state of immune dysregulation. The concept of immune dysregulation as a direct cause of autoimmunity in ...
Tolerance Induction at the Early Maternal–Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides
(Wiley, 2013-02)
Pregnancy challenges immune cells and immunomodulatory circuits of the mother and the developing fetus to dynamically adapt to each other in an homeostatic and tolerant environment for fetal growth. This entails the ...
Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity
(2021-12-07)
Monoclonal antibodies (mAbs) have been a valuable tool to elucidate several biological processes, such as stem cell differentiation and cancer, and contributed to virtually all areas of biomedical sciences. Yet, it remains ...