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IL-1β, IL-2 and IL-4 concentration during porcine gestation
(Elsevier Science Inc, 2019-04-01)
In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, ...
Altered expression of IL-1β IL-1RI, IL-1RII, IL-1RA and IL-4 could contribute to anovulation and follicular persistence in cattle
(Elsevier Science Inc, 2018-04)
Cystic ovarian disease (COD) is an important cause of infertility in dairy cattle. The main signs of this infertility are ovulation failure and follicular persistence. The aim of this study was to examine the expression ...
Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis
(Elsevier Ireland, 2006-06)
Experimental autoimmune orchitis (EAO) is an organ-specific model of autoimmunity characterized by an interstitial lymphomononuclear cell infiltrate as well as sloughing and apoptosis of germ cells. EAO was induced in adult ...
Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice
(Nature Publishing Group, 2020-05-19)
Psoriasis (PS) is a chronic skin inflammation. Up to 30% of the patients with PS develop psoriatic arthritis (PsA), a condition characterized by inflammatory arthritis that affects joints or entheses. Although there is ...
Staphylococcus aureus Induces Shedding of IL-1RII in Monocytes and Neutrophils
(Karger, 2016-03)
Interleukin 1 (IL-1) β is a critical cytokine that orchestrates host defenses against Staphylococcus aureus and is crucial for the eradication of bacteria. The production and action of IL-1β are regulated by multiple control ...
Programmed cell senescence: Role of IL-6 in the pituitary
(BioScientifica, 2017-05)
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, ...
Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8 + T cell development
(Public Library of Science, 2019-11)
Innate CD8 + T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in ...
Follicular structures of cows with cystic ovarian disease present altered expression of cytokines
(Cambridge University Press, 2019-08)
Ovulation is considered an inflammatory, cytokine-mediated event.Cytokines, which are recognized as growth factors with immunoregulatory properties, are involved in many cellular processes at the ovarian level. In this ...
Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils
(Frontiers Research Foundation, 2018-02)
Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which a canonical mechanism of ...
CFTR modulates RPS27 gene expression using chloride anion as signaling effector
(Elsevier Science Inc, 2017-09)
In Cystic Fibrosis (CF), the impairment of the CFTR channel activity leads to a variety of alterations, including differential gene expression. However, the CFTR signaling mechanisms remain unclear. Recently, culturing ...