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Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression
(Elsevier, 2017-04)
Histone post-translational modification, mediated by histone acetyltransferases and deacetylases, is one of the most studied factors affecting gene expression. Recent data showing differential histone acetylation states ...
Histone methylations in the developing central nervous system and in neural tube defects
(De Gruyter, 2018-05)
Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms ...
Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells
(Wiley, 2016-02-04)
Extracellular histones are highly augmented in sites of neovessel formation, such as regeneration tissues. We studied histone effect on survival and angiogenic activity of mature and progenitor endothelial cells. Extracellular ...
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
(BioMed Central, 2015)
Background:
Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of ...
A focus on the roles of histones in health and diseases
(Pergamon-Elsevier Science Ltd, 2021-08)
Over time, the knowledge on the role of histones has significantly changed. Initially, histones were only known as DNA packaging proteins but later, it was discovered that they act extracellularly as powerful antimicrobial ...
Heterogeneous distribution of histone methylation in mature human sperm
(Springer, 2014-01-31)
Purpose
To analyze the presence of various histone modifications in ejaculated human spermatozoa
Methods
In this prospective study, seminal ejaculates from 39 normozoospermic individuals were evaluated for semen analysis ...
Centromeric localization and adaptive evolution of an arabidopsis histone H3 variant
(American Society of Plant Biologist, 2002-12)
Centromeric H3-like histones, which replace histone H3 in the centromeric chromatin of animals and fungi, have not been reported in plants. We identified a histone H3 variant from Arabidopsis thaliana that encodes a ...
Cocaine alters the mouse testicular epigenome with direct impact on histone acetylation and DNA methylation marks
(Elsevier, 2018-09)
Research question: Recent evidence suggests that cocaine administration in animal models can trigger non-genetic inheritance of addiction traits from father to offspring, affecting development and behaviour. Is chronic ...
A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets
(Elsevier Science, 2019-03)
Background & Aims: A causal link has recently been established between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have therapeutic potential. We aimed to identify and target ...