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Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials.
(2018)
Background
To compare the efficacy and toxicity of the combination of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors and nonsteroidal aromatase inhibitors (AI) versus AI alone as first-line therapy for patients with ...
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom
(2000-01-01)
Myotoxin-I (MjTX-I) was purified to homogeneity from the venom of Bothrops moojeni by ion-exchange chromatography on CM-Sepharose. Its molecular weight, estimated by SDS–PAGE, was 13,400 (reduced) or 26,000 (unreduced). ...
Improving antivenom availability and accessibility: Science, technology, and beyond
(2012-09-15)
Snakebite envenomings constitute a serious and neglected public health problem. Despite the fact that effective treatment exists, i.e. administration of animal-derived antivenoms, the availability and accessibility of these ...
The exceptionally high life expectancy of Costa Rican nonagenarians
(Demography 45(3): 673–691, 2008-08)
Robust data from a voter registry show that Costa Rican nonagenarians have an exceptionally
high live expectancy. Mortality at age 90 in Costa Rica is at least 14% lower than an average of 13
high-income countries. This ...
Mapping research networks in basic sciences at University of Costa Rica
(Convergencia, 42, September-December 2006, 169-203, 2006-09)
Este trabajo es una contribución al estudio simultáneo de elementos ontológicos y
metodológicos comprometidos con el conocimiento de la organización sociotécnica de la investigación científica universitaria. Se trata de ...
A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
(2016-11-09)
Cancer complexity and resistance is mediated by
cell-to-cell heterogeneity, which is the consequence of the
enormous instability of its genetic material. It is unknown how
cancer cells are able to withstand the effects ...
Snakebites are associated with poverty, weather fluctuations, and El Niño
(2015-09-11)
Snakebites are environmental and occupational health hazards that mainly affect rural populations worldwide. The ectothermic nature of snakes raises the issue of how climate change’s impact on snake ecology could influence ...
Detection of proteins antigenically-related to Bothrops asper myotoxin in crotaline snake venoms
(1987)
The presence of components antigenically related to Bothrops asper myotoxin was investigated by Western blotting and immunoelectrophoretic techniques. B. asper myotoxin is a non-glycosylated monomeric phospholipase A with ...
Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?
(2010-01)
The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental ...
Effect of storage temperature on the stability of polyvalent antivenom produced in Costa Rica.
(1990)
The effect of storage temperature on the stability of the liquid polyvalent (crotaline) antivenom produced at the Instituto Clodomiro Picado, Costa Rica, was studied during a twelve-month period. The following parameters ...