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Influência das modificações pós-traducionais de histonas H3K4ME2, H3K4ME3 e H3K14AC no prognóstico e na sobrevida do carcinoma de células escamosas bucalInfluence of post-translational modifications of histone H3K4ME2, H3K4ME3 and H3K14AC on the prognosis and survival of oral squamous cell carcinoma
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Imunologia e Parasitologia Aplicadas, 2019)
O papel do complexo repressor de Polycomb 2 na assinatura epigenética de fatores de transcrição envolvidos na diferenciação de células mesenquinais derivadas tecido adiposo de camundongo obesos
(Universidade Federal de São Paulo, 2021-08-10)
A obesidade é uma doença crônica que leva a importantes alterações no tecido adiposo branco (TAB). As células tronco mesenquimais derivadas do tecido adiposo (Adipose derived Stromal Cells – AdSC) estão implicadas na ...
LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome
(Public Library of Science, 2016-07)
Precise expression patterns of genes in time and space are essential for proper development of multicellular organisms. Dynamic chromatin conformation and spatial organization of the genome constitute a major step in this ...
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
(Elsevier, 2018-10)
We have uncovered a role for Jumonji inhibitors in overcoming radioresistance through KDM5B inhibition. Pharmacological blockade of Jumonji demethylases with JIB-04 leads to specific accumulation of H3K4me3 at sites marked ...
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
(2020)
Background: Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...
Cell-type–specific transcriptome and histone modification dynamics during cellular reprogramming in the Arabidopsis stomatal lineage
(National Academy of Sciences, 2019-10-22)
Plant cells maintain remarkable developmental plasticity, allowing them to clonally reproduce and to repair tissues following wounding; yet plant cells normally stably maintain consistent identities. Although this capacity ...
Avaliação das modificações de histonas H3K36me3, H3K9ac, H4K12ac e H3S10ph em queilite actínica e carcinoma epidermóide de lábio
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Biologia Celular e Estrutural AplicadasCiências BiomédicasUFU, 2016)
Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation
(American Society for Microbiology, 2016-02)
Stem cell phenotypes are reflected by posttranslational histone modifications, and this chromatin-related memory must be mitotically inherited to maintain cell identity through proliferative expansion. In human embryonic ...
Alterações das marcas epigenéticas H3K9ac, H3K4me3, H3K27me3 ocorrem em promotores de genes relacionados à resposta imune inata em pacientes sépticos e estão relacionadas com diferentes desfechos clínicos
(Universidade Federal de São Paulo, 2023-04-27)
A sepse é uma das principais causas de morbidade e mortalidade no mundo. Sua fisiopatologia é bastante complexa, mas seus mecanismos ainda não são totalmente compreendidos. Monócitos e macrófagos parecem sofrer reprogramação ...
Changes in tri-methylation profile of lysines 4 and 27 of histone H3 in bovine blastocysts after cryopreservation
(Elsevier B. V., 2015)
Pregnancy rates from cryopreserved embryos remain lower than non-cryopreserved counterparts, even though these embryos appear morphologically normal. How epigenetic events, such as histone modifications, are affected by ...