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Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice
(2013-08-01)
Pharmacological manipulation of TRPV1 (Transient Receptor Potential Vanilloid type-1) receptors has been emerging as a novel target in the investigation of anxiety states. Here, we attempt to show the role played by the ...
ON THE VERGE OF A RESPIRATORY-TYPE PANIC ATTACK: SELECTIVE ACTIVATIONS OF ROSTROLATERAL AND CAUDOVENTROLATERAL PERIAQUEDUCTAL GRAY MATTER FOLLOWING SHORT-LASTING ESCAPE TO A LOW DOSE OF POTASSIUM CYANIDE
(Pergamon-Elsevier Science Ltd, 2017)
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated ...
Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: influence of prior local N-methyl-D-aspartate receptor activation and aversive condition
(Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio)Universidade de Brasília (UnB)Universidade de São Paulo (USP), 2010-06-01)
Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation ...
Activation of 5-HT2C receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze
(Elsevier B.V., 2012-11-01)
Several findings have pointed to the role of the dorsal periaqueductal gray (dPAG) serotonin 5-HT1A and 5-HT2(A-C) receptor subtypes in the modulation of defensive behavior in animals exposed to the elevated plus-maze ...
EVIDENCE of A SUFFOCATION ALARM SYSTEM WITHIN the PERIAQUEDUCTAL GRAY MATTER of the RAT
(Elsevier B.V., 2012-01-03)
Dyspnea, hunger for air, and urge to flee are the cardinal symptoms of panic attacks. Patients also show baseline respiratory abnormalities and a higher rate of comorbid and antecedent respiratory diseases. Panic attacks ...
Periaqueductal gray matter modulates the hypercapnic ventilatory response
(Springer, 2012-08-01)
The periaqueductal gray (PAG) is a midbrain structure directly involved in the modulation of defensive behaviors. It has direct projections to several central nuclei that are involved in cardiorespiratory control. Although ...
A panic attack-like unusual stress reaction
(Elsevier B.V., 2008-11-01)
Ever since the seminal studies of Hans Selye, activation of hypothalamus-pituitary-adrenal (HPA) axis is emblematic of stress. Consequently, the lack of HPA axis responses following the undisputable psychological stress ...
Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice
(Elsevier B.V., 1998-03-26)
Recent results from our laboratory have shown that 30-bites social conflict in mice produces a high-intensity, short-term analgesia which is attenuated by systemically injected 5-HT1A receptor agonists, such as BAY R 1531 ...