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VGLUTs and glutamate synthesis-focus on DRG neurons and pain
(MDPI, 2015-12)
The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of ...
Effect of Angeli's salt on the glutamate/glutamine cycle activity and on glutamate excitotoxicity in the hamster retina
(Pergamon-Elsevier Science Ltd, 2012-07)
Glutamate is the main excitatory neurotransmitter in the retina, but it is toxic when present in excessive amounts. It is well known that NO is involved in glutamate excitotoxicity, but information regarding the possibility ...
NMDA and group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence
(Elsevier Ireland, 2006-01)
Glutamate participates in the regulation of secretion of several neuropeptides, including substance P (SP). Glutamate acts through ionotropic (iGluRS) and metabotropic (mGluRS) receptors. We have investigated whether ...
Glutamate Induces Apoptosis in Anterior Pituitary Cells through Group II Metabotropic Glutamate Receptor Activation
(Endocrine Society, 2004-10)
Glutamate can induce neuronal cell death by activating ionotropic glutamate receptors (iGluRs) as well as metabotropic glutamate receptors (mGluRs). In the present study, we investigated whether glutamate induces apoptosis ...
Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine
(Wiley-liss, div John Wiley & Sons Inc., 2018-11)
When activated, microglial cells have the potential not only to secrete typical proinflammatory mediators but also to release the neurotransmitter glutamate in amounts that may promote excitotoxicity. Here, we wished to ...
Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens
(Wiley Blackwell Publishing, Inc, 2021-03)
Altered glutamate transmission within the nucleus accumbens (NAc) has been proposed as a central mechanism underlying behavioural sensitisation associated with repeated cocaine exposure. In addition to glutamate, enkephalin, ...
Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
(Pergamon-Elsevier Science Ltd, 2005-06)
The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two ...
Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.
(Wiley Blackwell Publishing, Inc, 2009-12)
Retinal ischemia could provoke blindness and there is no effective treatment against retinal ischemic damage. Brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina ...
Novel glutamate dehydrogenase genes show increased transcript and protein abundances in mature tomato fruits
(Elsevier Gmbh, 2012-06)
NAD(P)H-glutamate dehydrogenase (GDH, EC 1.4.1.3) contributes to the control of glutamate homeostasis in all living organisms. In bacteria and animals, GDH is a homohexamer allosterically regulated, whereas in plants ...
Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na+/K+-ATPase in brain tissue in vitro
(Wiley Blackwell Publishing, Inc, 2004-11)
1. It has been suggested that Na+/K+-ATPase and Na+-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K +-ATPase activity using Rb+ uptake by 'minislices' ...