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Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

Tamar Silva, Claudia; Kors, Jan A.; Amin, Najaf; Dehghan, Abbas; Witteman, Jacqueline C. M.; Willemsen, Rob; Oostra, Ben A.; van Duijn, Cornelia; Isaacs, Aaron (2015)

Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

Petermann, Fanny; Villagrán, Marcelo; Troncoso, Claudia; Mardones, Lorena; Leiva, Ana María; MartÍnez, María Adela; Garrido-Méndez, Alex; Poblete-Valderrama, Felipe; Salas-Bravo, Carlos; Ramírez-Vélez, Robinson; Arbeláez Ulloa, Natalia; Pérez-Bravo, Francisco; Celis-Morales, Carlos (2018)

Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and ...

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

Lessard, Christopher J.; Adrianto, Indra; Kelly, Jennifer A.; Kaufman, Kenneth M.; Grundahl, Kiely M.; Adler, Adam; Williams, Adrienne H.; Gallant, Caroline J.; Alarcón-Riquelme, Marta E.; Anaya, Juan-Manuel; Bae, Sang-Cheol; Boackle, Susan; Brown, Elizabeth E.; Chang, Deh-Ming; Criswel, Lindsey A.; Edberg, Jeffrey C.; Freedman, Barry I.; Gregersen, Peter K.; Gilkeson, Gary S.; Jacob, Chaim O.; James, Judith A.; Kamen, Diane L.; Kimberly, Robert P.; Martin, Javier; Merrill, Joan T.; Niewold, Timothy B.; Park, So-Yeon; Petri, Michelle A.; Pons-Estel, Bernardo A.; Ramsey-Goldman, Rosalind; Reveille, John D.; Song, Yeong Wook; Stevens, Anne M.; Tsao, Betty P.; Vila, Luis M.; Vyse, Timothy J.; Yu, Chack-Yung; Guthridge, Joel M.; Bruner, Gail R.; Langefeld, Carl D.; Montgomery, Courtney; Harley, John B.; Scofield, Robert H.; Gaffney, Patrick M.; Moser, Kathy L. (2011)

Genetics and autoantibodies

Perricone, Carlo; Agmon-Levin, Nancy; Ceccarelli, Fulvia; Valesini, Guido; Anaya, Juan-Manuel; Shoenfeld, Yehuda

Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal ...

Familial autoimmune thyroid disease and PTPN-22

CONZUELO RODRIGUEZ, GABRIEL; 415447; Mendieta Zerón, Hugo; 45175; CONZUELO RODRIGUEZ, GABRIEL; Mendieta Zerón, Hugo (Medicinski Glasnik, 2020)

Epstein-Barr virus and cytomegalovirus in autoimmune diseases are they truly notorious? A preliminary report

Anaya, Juan-Manuel; Ram, M.; Sherer, Y.; Shoenfeld, Y.

To date, it is believed that the origin of autoimmune diseases is one of a multifactorial background. A genetic predisposition, an immune system malfunction or even backfire, hormonal regulation, and environmental factors ...

The quest for immunotherapy in atherosclerosis: CANTOS study, interleukin-1β and vascular inflammation

Bermúdez, Valmore; Rojas-Quintero, Joselyn; Velasco, Manuel (AME Publishing Company, 2017-12)

espite the monumental efforts directed into studying and describing the pathways, factors, genetic predisposition, and target-specific pharmacotherapy to atherosclerosis, ischemic heart disease, thrombotic cerebrovascular ...

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

Lessard, Christopher J.; Adrianto, Indra; Ice, John A.; Wiley, Graham B.; Kelly, Jennifer A.; Glenn, Stuart B.; Adler, Adam J.; Li, He; Rasmussen, Astrid; Williams, Adrienne H.; Ziegler, Julie; Comeau, Mary; Marion, Miranda; Wakeland, Benjamin E.; Liang, Chaoying; Ramos, Paula S.; Grundahl, Kiely M.; Gallant, Caroline J.; Alarcón-Riquelme, Marta E.; Alarcón, Graciela S.; Anaya, Juan-Manuel; Bae, Sang-Cheol; Boackle, Susan; Brown, Elizabeth E.; Chang, Deh-Ming; Cho, Soo-Kyung; Criswel, Lindsey A.; Edberg, Jeffrey C.; Freedman, Barry I.; Gilkeson, Gary S.; Jacob, Chaim O.; James, Judith A.; Kamen, Diane L.; Kimberly, Robert P.; Kim, Jae-Hoon; Martin, Javier; Merrill, Joan T.; Niewold, Timothy B.; Park, So-Yeon; Petri, Michelle A.; Pons-Estel, Bernardo A.; Ramsey-Goldman, Rosalind; Reveille, John D.; Scofield, Robert H.; Song, Yeong Wook; Stevens, Anne M.; Tsao, Betty P.; Vila, Luis M.; Vyse, Timothy J.; Yu, Chack-Yung; Guthridge, Joel M.; Kaufman, Kenneth M.; Harley, John B.; Wakeland, Edward K.; Langefeld, Carl D.; Gaffney, Patrick M.; Montgomery, Courtney G.; Moser, Kathy L. (2012)

Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years

Brunotto, M.; Zarate, AM.; Bono, A.; Barra, JL.; Berra, S. (2014-03)

Head and Neck Carcinoma (HNC), of which the majority are squamous cell carcinomas of the head and neck (SCCHN), is the sixth most prevalent cancers in mankind and, presents high morbidity and low rates of survival.1 It is ...

Primary immunodeficiency and autoimmunity: A comprehensive review

Amaya-Uribe L.; Rojas M.; Azizi G.; Anaya, Juan-Manuel; Gershwin M.E.

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved ...