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Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified ...
Allyltrichlorostannane additions to alpha-amino aldehydes: Application to the total synthesis of the aspartyl protease inhibitors L-682,679, L-684,414, L-685,434, and L-685,458
(Georg Thieme Verlag KgStuttgartAlemanha, 2003)
Short total synthesis of aspartyl protease inhibitors L-685,434, L-682,679 and L-685,458
(Georg Thieme Verlag KgStuttgartAlemanha, 2002)
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor
(Wiley-liss, Div John Wiley & Sons Inc, 2017-12-20)
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed. ...
UV Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport
(Society for Neuroscience, 2014-03)
Overexpression and/or abnormal cleavage of amyloid precursor protein (APP) are linked to Alzheimer's disease (AD) development and progression. However, the molecular mechanisms regulating cellular levels of APP or its ...
Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2-and gamma-secretase inhibitors
(Ferrata Storti FoundationPaviaItália, 2010)