Artículos de revistas
Allyltrichlorostannane additions to alpha-amino aldehydes: Application to the total synthesis of the aspartyl protease inhibitors L-682,679, L-684,414, L-685,434, and L-685,458
Registro en:
Synthesis-stuttgart. Georg Thieme Verlag Kg, n. 4, n. 603, n. 622, 2003.
0039-7881
WOS:000181727400024
Autor
Dias, LC
Diaz, G
Ferreira, AA
Meira, PRR
Ferriera, E
Institución
Resumen
The hydroxyethylene dipeptide isostereS L-6,82,679, L-684,414, L-685,434, and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with ad alpha-amino aldehyde, followed by hydroboration of the corresponding 1,2-syn and 1,2-anti amino alcohols to give the diols, lactonization under TPAP conditions, lactone opening, and peptide coupling with the desired amine or dipeptide amide. The present synthetic approach represents a practical entry to a large range of other dipeptide isosteres. 4 603 622