Hydroxyethylene dipeptide isosteres L-685,434, L682,679 and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an alpha-aminoaldehyde followed by hydroboration of the corresponding 1,2syn and 1,2-anti aminoalcohols to give the diols, lactonization under TPAP conditions, lactone opening and peptide coupling with the desired amine or dipeptide amide.o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.1118451849