Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ...

Motor Neuron Disease disorders, described in domestic animals, are characterized by neuronal degeneration at the spinal cord. Excitotoxicity is a crucial factor for the selective loss of these neurons, being the fundamental ...

Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several receptors, including ionotropic N-me ...

Excitotoxic levels of released glutamate trigger a cascade of deleterious cellular events leading to delayed neuronal death. This phenomenon implies extensive dysregulation in the balance between network excitation and ...

Introduction: Neurodegenerative disorders are strongly associated to excitotoxicity, i.e. neuronal death by pathological stimulation of N-methyl-D-aspartate (NMDA) receptors in susceptible areas of the central nervous ...

Neurodegenerative disorders are strongly associated to excitotoxicity, i.e. neuronal death by pathological stimulation of N-methylD-aspartate (NMDA) receptors in susceptible areas of the central nervous system. Neuronal ...

Introduction: Excitotoxicity, i.e. neuronal death by excessive NMDA receptor activation, neuronal Ca2+ overload and nitric oxide (NO) synthesis, is a prominent mechanism leading to cell death (Sandoval et al. 2011, J ...

Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-beta peptide oligomers, which promote excessive ...