The transcription factor NF-kB is translocated to the nucleus in epilepsy-related excitotoxicity.

Abstract

Neurodegenerative disorders are strongly associated to excitotoxicity, i.e. neuronal death by pathological stimulation of N-methylD-aspartate (NMDA) receptors in susceptible areas of the central nervous system. Neuronal death depends on NMDA-receptor medi